肥厚心肌细胞钠通道电流  

Sodium Channel Current In Hypertrophied Myocardiocytes in Spontaneously hypertensive Rat

作　　者：黄至斌[1] 伍卫[1] 方昶[1] 韦育林[1] 

机构地区：[1]中山大学附属第二医院心内科,广州510120

出　　处：《中华高血压杂志》2007年第3期241-245,共5页Chinese Journal of Hypertension

摘　　要：目的探讨自发高血压大鼠(SHR)肥厚心肌钠通道电流的动态演变规律及与左心室肥厚的关系。方法采用全细胞膜片钳技术记录10、24和34周龄SHR左心室心肌钠通道电流及膜电容,同时测定大鼠动脉收缩压和左心室质量指数,以10周龄Wistar大鼠为对照组。结果(1)SHR的左心室质量指数及膜电容明显大于Wistar大鼠(P<0.01)。在SHR中,各组大鼠的膜电容和左心室质量指数具有明显差别(P<0.01)。(2)10周龄和24周龄SHR肥厚心肌钠通道电流密度与10周龄Wistar大鼠比较无明显变化(P>0.05);34周龄SHR肥厚心肌钠通道电流密度>10周龄Wistar大鼠[(-18.3±1.9)pA/pFvs(-15.3±2.0)pA/pF,P<0.05)。(3)钠通道电流密度与左心室质量指数呈正相关关系(r=0.879,P<0.01)。结论左心室肥厚越明显,钠通道电流密度越升高。Objective To study the change in sodium channel current（ⅠNa）in the developement of the left ventricular hypertrophy in spontaneously hypertensive rat（SHR）.Methods ⅠNa and membrane capacitance（MC）were measured in myocytes of 10,24 and 34-week SHR by the whole-cell patch-clamp technique.Systolic blood pressure（SBP）and left ventricular mass index（LVMI）were detemined.10-week old Wistar rats served as controls.Results LVMI and MC of SHR were significantly higher than those of Wistar rat（P〈0.01）.LVMI and MC were significantly different among 3 age groups of SHR （P〈0.01）. The density of ⅠNa in 10 and 24-week SHR were of no different from that of 10-week Wistar rat （P〉0.05）, however the density of ⅠNa in 34- week SHR were higher than those of Wistar rat （-18. 3±1.9） vs （-15. 3±2. 0）pA/pF,P〈0. 05）. The density of ⅠNa was significantly related with LVMI（r=0. 879, P〈0.01）. Conclusion The density of ⅠNa in myocytes was associate with the degree of hypertrophy of left ventriele.

关 键 词：高血压 左心室肥厚 离子通道 钠通道 

分 类 号：R541[医药卫生—心血管疾病]