颗粒酶B:有力的细胞免疫杀伤因子  

Granyme B:A Powerful Killer in Cellular Immunity

作　　者：李一叶[1] 卢圣栋[1] 

机构地区：[1]中国医学科学院基础医学研究所,中国协和医科大学基础医学院医学分子生物学国家重点实验室,北京市100005

出　　处：《医学分子生物学杂志》2007年第2期121-124,共4页Journal of Medical Molecular Biology

摘　　要：丝氨酸蛋白酶家族成员颗粒酶B是细胞毒淋巴细胞介导的颗粒胞吐免疫效应中有力的杀伤因子。近年来,颗粒酶B与穿孔素协同作用的靶细胞摄取机制受到质疑,“受体内化”及“静电交换”等新模型被相继提出。颗粒酶B在靶细胞内能够诱导caspase依赖及非依赖性的凋亡,还能直接作用于死亡底物发挥细胞毒作用,同时具有基质重塑等重要的细胞外功能。颗粒酶B与自身免疫疾病及抗病毒感染密切相关,在恶性肿瘤细胞杀伤方面的应用价值正日益受到关注。Lymphocytes-mediated cytotoxicity works mainly through granules exocytosis. Granzyme B is one of the powerful members of the granule toxins. While there is widespread acceptance of the existence of the perforin/granzyme B synergy, the receptor-mediated internalization and the electrostatic ＂ exchange-adsorption＂ model, the mechanism underlying the binding and uptake of granzyme B by target cells is still controversial. Within the target cells, granzyme B rapidly activates caspase-dependent and/or caspase-independent apoptosis and induces cytotoxicity by directly cleaving a variety of death substrates. It also has other important extracellular functions, e. g. matrix remodeling. Granzyme B is closely related to autoimmune diseases and anti-virus infection process. It is attracting increasing attention for its application in cancer treatment.

关 键 词：颗粒酶B 细胞毒淋巴细胞 凋亡 

分 类 号：R392.11[医药卫生—免疫学]