银屑病患者甲襞微循环改变的临床意义  

Clinical significance of changes of nail fold microcirculation in psoriatics

作　　者：薛竞[1] 王尚兰[1] 

机构地区：[1]四川省人民医院皮肤性病研究所,四川成都610072

出　　处：《实用医院临床杂志》2007年第3期50-51,共2页Practical Journal of Clinical Medicine

摘　　要：目的探讨检测银屑病患者甲襞微循环改变的临床意义。方法选用国产麦赛3-999Ⅱ型微循环显微镜在室温（18—25℃）下观察50例银屑病患者的左手无名指甲襞微循环，同时与20例健康人作对照。检测管袢形态、流态、袢周状态等指标。结果管袢形态：寻常型银屑病（0．98±0．38）分，红皮病型银屑病3．64分，脓疱型银屑病3．95分；对照组（0．95±0．32）分。流态：寻常型银屑病（1．21±0．38）分，红皮痛型银屑痛0．81分，脓疱型银屑病0．78分；对照纽（1．01±0．36）分。袢周状态：寻常型银屑病（0．96±0．41）分，红皮病型银屑病4．21分，脓疱型银屑病4．09分；对照组（0．78±0．46）分。对照组与寻常型银屑病组比较差异有极显著性意义（P〈0．005）。结论银屑病的甲襞微循环改变以管袢畸形、袢周渗出和出血改变为主，且微循环障碍的程度与病情严重程度成正相关。Objective To study the changes of nail fold microcirculation in psoriatic patients. Methods Fifty cases of psoriasis, including 37 cases of psoriasis vulgaris, 9 cases of psoriasis erythrodermia , 4 cases of psoriasis pustulosi, were classi- fied into therapy group and other 20 healthy subjects served as control. Using MAISAI3-999 Ⅱ microscope connected with a computer, we detected the loop shape, flow state, and periloop state. Results The loop shape was （ 0. 98 ± 0. 38 ） in cases of psoriasis vulgaris, 3.64 in psoriasis erythrodermia, 3.95 in psoriasis pustulosis, and （ 0.95 ± 0. 32 ） in controls. Flow state was （ 1.21±0. 38 ） in psoriasis vulgaris, 0. 81 in psoriasis erythrodermia, 0. 78 in psoriasis pustulosis, and（ 1.01±0. 36） in controls. Periloop state was （ 0. 96 ± 0.41 ） in psoriasis vulgaris, 4. 21 in psoriasis erythrodermia, 4. 09 in psoriasis pustulosis, and （ 0. 78 ± 0. 46 ） in controls. There was significant difference between psoriasis vulgaris and controls （ P 〈 0. 005 ）. Conclusion There are obvious changes in nail fold microcirculation in patients with psoriasis and the extent of microcirculation disturbance is positively correlated with the severity of pathogenetic conditions.

关 键 词：银屑病 甲襞微循环 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]