黄芩素胶囊的小鼠急性毒性实验  

Acute Toxicity Test of Baicalein Capsule in Mice

作　　者：张喜平[1] 程琪辉[2] 陈君峰[3] 毛嘉宾[3] 陆贝[1] 居同法[1] 

机构地区：[1]杭州市第一人民医院普外科,310006 [2]杭州市第一人民医院妇产科,310006 [3]浙江中医药大学

出　　处：《医学研究杂志》2007年第4期52-55,共4页Journal of Medical Research

基　　金：浙江省中医药卫生科技计划项目(2003C130);杭州市重大科技发展计划项目(2003123B19);杭州市医药卫生重点项目(2004Z006)

摘　　要：目的观察黄芩素胶囊灌胃一日后产生的急性毒性反应和死亡情况。方法将黄芩素胶囊的内容物黄芩素粉以最大浓度给ICR小鼠灌胃给药,小鼠未出现死亡,未测出LD50,故测其最大给药量。结果黄芩素粉最大给药量为15g/Kg。结论黄芩素胶囊具有较好的安全性。Objective To observe the acute toxic reaction and death of mice one day after intragastric administration of Baicalein capsule so as to appraise its safety. Methods The ICR mice were intragastrically administered with Baicalein powder at maximum concentration. There was no death of mice found and no LD50 detected. Hence the maximum dosage was measured. Results The maximum dosage of Baicalein powder is 15g/kg. Conclusions The Baicalein capsule is relatively safe.

关 键 词：汉黄芩素 急性毒性实验 小鼠 

分 类 号：R285.5[医药卫生—中药学]