地塞米松对阿曲库铵神经阻滞效应的影响  

Effects of dexamethasone on neuromuscular blocking efficiency of atracurium

作　　者：郭维嘉[1] 苗壮[1] 肖昭扬[1] 杨毅欣 

机构地区：[1]大连医科大学第一临床学院麻醉科,辽宁大连116011 [2]美国堪萨斯州安玻利亚州立大学生物科学系,堪萨斯州安玻利亚66801

出　　处：《大连医科大学学报》2007年第2期149-150,共2页Journal of Dalian Medical University

摘　　要：[目的]观察地塞米松对阿曲库铵神经肌肉阻滞效应的影响。[方法]选择择期甲状腺肿物切除术病人80例,随机分成两组:地塞米松组,麻醉诱导前静脉注射地塞米松10 mg,10 min后按顺序静脉注射咪唑安定0.1 mg/kg、芬太尼4μg/kg、丙泊酚2 mg/kg、阿曲库铵0.6 mg/kg;对照组,麻醉诱导前给予同等剂量生理盐水,之后给予相同剂量麻醉诱导药物。观测两组患者拇内收肌群TOF,记录T1消失的时间及第1次T0F恢复时T1出现的时间。[结果]地塞米松组阿曲库铵起效时间为(289.0±19.7)s,比对照组(226.4±11.2)s明显延长,恢复时间为(13.7±0.5)min,比对照组(20.8±3.2)min明显缩短(P<0.05)。[结论]地塞米松可减弱阿曲库铵对全麻病人的神经肌肉阻滞效应。[ Objective] To observe the effects of dexamethasone on neuromuscular blocking efficiency of atracurium. [ Methods] Eighty patients with ASA Ⅰ- Ⅱ who underwent thyroid surgery were randomly divided into two groups ： dexamethasone group, the patients received intravenously 10 mg dexamethasone before anesthesia induction, then were given midazolam 0. 1 mg/kg, fentanyl 4 μg/kg, propofol 2 mg/kg, atracurium 0.6 mg/kg;control group, the patients were given same volume saline before anesthesia induction,then anesthesia induction were taken with same drugs and dosage. Train- of- four（TOF） were applied to ulnar nerve -adductor pollicis, time of T1 disappeared and recovered at first time was recorded. [ Results ] Time of onset of atracurium of Dexamethasone group （289.0 ± 19.7 ）s prolonged significantly than that of control group （226.4 ± 11.2）s （P 〈0.05 ）; and recovery time of atracurium of Dexamethasone group （ 13.7 ± 0.5 ） min was shorter significantly than that of control group （ 20.8 ± 3.2 ） min （ P 〈 0.05 ）. [ Conclusion] Dexamethasone may attenuate the efficiency of neuromascular blockage of atracurium.

关 键 词：地塞米松 阿曲库铵 神经阻滞效应 

分 类 号：R614[医药卫生—麻醉学]