肝脏趋化因子RANTES水平与慢性乙型肝炎患者临床分度的关系  

The relationship between the level of hepatic RANTES and clinical stages of patients with chronic hepatitis B

作　　者：尉秀清[1,2] 文幸夫[1] 郑丰平[1] 姚集鲁[2] 

机构地区：[1]中山大学附属第三医院消化内科,广东广州510630 [2]中山大学附属第三医院感染科,广东广州510630

出　　处：《中国医师杂志》2007年第4期458-460,共3页Journal of Chinese Physician

摘　　要：目的探讨慢性乙型肝炎患者肝脏组织趋化因子RANTES水平与临床分度的关系。方法用免疫组织化学染色及图像分析系统定量检测64例慢性乙型肝炎患者和10例正常人肝组织趋化因子RANTES表达。结果慢性乙型肝炎组的肝组织RANTES的表达量较正常对照组显著为高；正常对照和轻、中、重慢性乙型肝炎患者肝脏组织趋化因子RANTES水平分别3．7±1．5，15.6±6．9，24．0±4、0.37．9±11．1阳性单位值，随着慢性乙型肝炎患者临床分度的增加，肝组织RANTES的表达强度逐渐升高且各级之间比较差异均具有统计学意义。结论趋化因子RANTES在慢性乙型肝炎的发病机制中可能具有重要的作用。Objective To study the relationship between the clinical stages and the expression of chemokine RANTES in livers of patients with chronic hepatitis B, Methods Liver specimens from 64 patients with chronic hepatitis B and 10 normal subjects were divided into normal control, mild, moderate and serious chronic hepatitis B group according to the degree of clinical behavior. The expression of RANTES of the liver was studied by immunohistochemistry staining and morphometric quantitative measurement. Results The expression of RANTES in livers of patients with chronic hepatitis B virus infection was significantly higher than that in the normal control（ P 〈 0. 05 ）. The expression of hepatic R.ANTES in normal control, mild, moderate and marked chronic hepatitis B group were 3.7 ± 1.5,15.6 ± 6. 9,24.0 ± 4.0 and 37. 9± 11.1 positive units. From normal control group to serious chronic hepatitis B group, hepatic RANTES level increased gradually and the differences between each group were significant （ P 〈 0. 05 ）, Conclusion Chemokine RANTES may play an important role in the pathogenesis of chronic hepatitis B.

关 键 词：肝 RANTES 肝炎 乙型 

分 类 号：R51[医药卫生—内科学]