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作 者:王玉彬[1] 陈安民[1] 郭风劲[1] 夏玉军[2]
机构地区:[1]华中科技大学同济医学院附属同济医院,湖北武汉430030 [2]青岛大学医学院
出 处:《山东医药》2007年第12期11-12,共2页Shandong Medical Journal
摘 要:目的观察骨关节炎(OA)关节软骨中肿瘤坏死因子α(TNF-α)、转化生长因子β(TGF-β)、白细胞介素-6(IL-6)和白细胞介素-9(IL-9)的表达变化,探讨其与软骨退变的关系。方法选取20例因OA行关节置换患者的软骨组织,常规HE染色观察其组织形态,免疫组化ABC法检测关节软骨组织中的TNF-α、TGF-β和IL-6、IL-9;2例因意外受伤截肢患者的正常膝关节软骨作为对照。结果OA患者关节软骨出现裂隙、纤维化,软骨细胞增多、排列紊乱,并出现大量簇聚软骨细胞和肥大软骨细胞。TNF-α和IL-6在正常软骨全层均呈低表达,在OA患者软骨中的表达则明显增多(P<0.01)。结论OA患者关节软骨中TNF-α、IL-6与TGF-β、IL-9表达失衡,是导致关节软骨退变的原因之一。[Objective] To investigate the relationship between degeneration of cartilage and the tumor necrosis factor α(TNF-α), transforming growth factor β (TGF-β), interleukin 6 (1L-6), IL-9 in osteoarthritis (OA). [MethodsI The histological changes of cartilages by hematoxyllin-eosin staining and immunohistochemical. The expression of TNF-α,TGF-β,IL-6 and IL-9 were studied in 20 OA cases and 2 normal controls. [Results] The OA cartilage showed fibroplasias. The quantity of chondrocyte increased and the clustered and hypertrophic cells came into being. Little TNF-α and IL-6 was observed in normal cartilage, while their expressions increased in degenerated cartilage of OA (P 〈 0.01). [Conclusions] The abnormal expression of TNF-α,IL-6 and TGF-β,IL-9 is likely to be the pathogenesis of cartilage degeneration.
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