骨关节炎患者软骨组织中TNF-α、TGF-β、IL-6、IL-9的表达变化及意义  被引量:32

Expression and significance of TNF-α,IL-6,TGF-β and IL-9 in osteoarthritis

在线阅读下载全文

作  者:王玉彬[1] 陈安民[1] 郭风劲[1] 夏玉军[2] 

机构地区:[1]华中科技大学同济医学院附属同济医院,湖北武汉430030 [2]青岛大学医学院

出  处:《山东医药》2007年第12期11-12,共2页Shandong Medical Journal

摘  要:目的观察骨关节炎(OA)关节软骨中肿瘤坏死因子α(TNF-α)、转化生长因子β(TGF-β)、白细胞介素-6(IL-6)和白细胞介素-9(IL-9)的表达变化,探讨其与软骨退变的关系。方法选取20例因OA行关节置换患者的软骨组织,常规HE染色观察其组织形态,免疫组化ABC法检测关节软骨组织中的TNF-α、TGF-β和IL-6、IL-9;2例因意外受伤截肢患者的正常膝关节软骨作为对照。结果OA患者关节软骨出现裂隙、纤维化,软骨细胞增多、排列紊乱,并出现大量簇聚软骨细胞和肥大软骨细胞。TNF-α和IL-6在正常软骨全层均呈低表达,在OA患者软骨中的表达则明显增多(P<0.01)。结论OA患者关节软骨中TNF-α、IL-6与TGF-β、IL-9表达失衡,是导致关节软骨退变的原因之一。[Objective] To investigate the relationship between degeneration of cartilage and the tumor necrosis factor α(TNF-α), transforming growth factor β (TGF-β), interleukin 6 (1L-6), IL-9 in osteoarthritis (OA). [MethodsI The histological changes of cartilages by hematoxyllin-eosin staining and immunohistochemical. The expression of TNF-α,TGF-β,IL-6 and IL-9 were studied in 20 OA cases and 2 normal controls. [Results] The OA cartilage showed fibroplasias. The quantity of chondrocyte increased and the clustered and hypertrophic cells came into being. Little TNF-α and IL-6 was observed in normal cartilage, while their expressions increased in degenerated cartilage of OA (P 〈 0.01). [Conclusions] The abnormal expression of TNF-α,IL-6 and TGF-β,IL-9 is likely to be the pathogenesis of cartilage degeneration.

关 键 词:肿瘤坏死因子Α 白细胞介素 转化生长因子Β 骨关节炎 

分 类 号:R681.1[医药卫生—骨科学]

 

参考文献:

正在载入数据...

 

二级参考文献:

正在载入数据...

 

耦合文献:

正在载入数据...

 

引证文献:

正在载入数据...

 

二级引证文献:

正在载入数据...

 

同被引文献:

正在载入数据...

 

相关期刊文献:

正在载入数据...

相关的主题
相关的作者对象
相关的机构对象