306例男性血糖水平和动脉血压及血浆皮质醇水平的关系及其可能机制  

Relationship among the levels of plasma glucose and cortisol and blood pressure and its possible mechanism

作　　者：张永生[1] 楚立云[1] 辛苏宁[1] 庞继恩[1] 叶勇[1] 

机构地区：[1]解放军第401医院心内科,山东青岛266071

出　　处：《中国现代医学杂志》2007年第7期837-838,共2页China Journal of Modern Medicine

基　　金：2000年海军医药卫生科研究计划课题(00HW008)

摘　　要：目的探讨血糖水平和动脉血压及血浆皮质醇水平的关系及其可能机制。方法随机选取306例男性,根据血糖情况进行分组,测定血压及血浆皮质醇水平并进行相关分析。结果随着血糖水平的增高,血压及血浆皮质醇水平也相应增高(P<0.01);血糖水平与收缩压、舒张压及血浆皮质醇水平呈明显正相关(分别是r=0.55,P<0.01;r=0.48,P<0.01;r=0.46,P<0.01)。结论葡萄糖可能通过抑制11β羟化固醇脱氢酶2型的催化活性,致使血浆皮质醇水平升高诱导高血压。[Objective] To search for the relationship among the levels of plasma glucose and cortisol and blood pressure and its possible mechanism. [Methods] 306 men were divided into four groups according to their levels of plasma glucose. Their blood pressure and plasma cortisol level were determined. Relative analysis was made between plasma glucose level and systolic blood pressure and diastolic blood pressure between plasma glucose level and cortisol level. [Results] The higher the level of plasma glucose, the more obviously the blood pressure and plasma cortisol level were increased （P 〈0.01）. The level of plasma glucose was positively correlated with the blood pressure and plasma cortisol level （r =0.55, P 〈0.01; r =0.48, P 〈0.01; r =0.46, P 〈0.01） respectively. [Conclusion] Glucose may result in hypertension because of increased level of plasma cortisol which is caused by inhibition of the enzyme of 11β-hydroxysteroid dehydrogenase type Ⅱ.

关 键 词：葡萄糖 动脉血压 11β羟化固醇脱氢酶2型 皮质醇 

分 类 号：R544.1[医药卫生—心血管疾病]