转录因子E2F-1在梗阻性肾组织中的表达及其意义  

Expression of transcription factor E2F-1 in chronic obstructive kidneys

作　　者：谢庆祥 林吓聪 韩聪祥 

机构地区：[1]福建省漳州市解放军第175中心医院泌尿外科,福建漳州363000

出　　处：《中国现代医学杂志》2007年第7期871-873,共3页China Journal of Modern Medicine

基　　金：福建省自然科学基金(Z0516082);漳州市科技计划项目(Z05068)

摘　　要：目的探讨转录因子E2F-1在梗阻性肾病的发病机制中作用。方法应用免疫组化方法检测E2F-1和增殖细胞核抗原(PCNA)在43例梗阻性肾组织和12例正常肾组织中的表达。分析E2F-1表达与梗阻性肾积水和肾纤维化程度之间关系。结果正常肾组织中E2F-1阳性表达率为41.7%,显著低于梗阻肾组织的79.1%(P<0.05)。梗阻肾组织E2F-1表达与肾纤维化程度及PCNA指数密切相关(P<0.05),但与肾积水程度无显著相关性(P>0.05)。结论E2F-1异常表达参与梗阻性肾病的发病过程,尤其在肾纤维化过程中发挥重要作用。[Objectives] To investigate the role of transcription factor E2F-1 in molercular pathogenesis of chronic obstructive kidney （COK）. [Methods] The immunohistochemistry methods was adopted to examine the expressions of E2F-1 and proliferation cell nuclear antigen （PCNA） in 43 cases with COK and 12 cases with normal renal tissues. The relationships between expression of E2F-1 and degree of hydronephrosis and renal fibrosis were evaluated. [Results] 41.7% of E2F-1 positive expression rate was found in normal renal tissues, which significantly lower than 79.1% in COK （P 〈0.05）. Expressions of E2F-1 in COK were close associated with degree of renal fibrosis and PCNA index （P 〈0,05）, while insignificantly associated with degree of hydronephrosis （P 〉0.05）. [ Conclusion] Abnormality of E2F-lexpression is involved in development and progression of COK, especially plays an important role in renal fibrosis.

关 键 词：肾 肾积水 梗阻性肾病 转录因子 

分 类 号：R692.2[医药卫生—泌尿科学]