矽肺动物模型全肺灌洗治疗的病理观察  

Pathologic observation on experimental silicosis treated with whole lung lavage

作　　者：谈万联[1,2] 夏开屏 张元庆 刘正华[1,2] 

机构地区：[1]南京胸科医院 [2]南京医科大学附属第一医院

出　　处：《中华劳动卫生职业病杂志》1997年第1期22-24,共3页Chinese Journal of Industrial Hygiene and Occupational Diseases

摘　　要：通过对动物模型实验治疗的病理观察，评价全肺大容量灌洗治疗矽肺的效果，并优选灌洗液。对４０只家兔和１０只幼猪经ＳｉＯ２染尘处理后，各随机分为药物组、盐水组和对照组。４～５周后施行全肺大容量灌洗。治疗后３～５个月处死各组动物，进行病理双盲检查。经统计学秩和检验，兔与猪各组肺矽结节纤维化级别分布的差异有非常显著意义（Ｐ＜０．００５）。经卡方检验，各灌洗组的纤维化程度与对照组相比，差异亦有非常显著意义（Ｐ＜０．０１）。灌洗液中药与盐水比，Ｐ＜０．０５；盐水与西药比，Ｐ＜０．０５。兔和猪矽肺各灌洗组的效果明显优于对照组。灌洗液中药优于盐水。To evaluate the therapeutic effect of whole lung lavage and to find out better lavage fluid by pathologic observation.Experimental silicosis was produced in 40 rabbits and 10 pigs.These rabbits and pigs were randomly divided into normal saline(NS) group,medicine group and control group.Whole lung lavage was performed 5 weeks after dusting on rabbits and 4 weeks after dusting on pigs.3 and 5 months after lung lavage,all rabbits and pigs were killed respectively for pathologic examination.The fibrotic degree of silicotic nodules among various groups of rabbits and pigs was highly significantly different by Rank test, P <0.005.The fibrotic grade of silicotic nodules in any group of lung lavage was signifcantly lower than that in control group by χ 2 test, P <0.05～0.01.The lavage fluids:herb medicine vs NS, P <0.05;NS vs western medicine, P <0.05.Experimental silicotic rabbits and pigs treated with whole lung lavage had their significantly superior effect than those in control groups.As for lavage fluids,herb medicine was better than NS,and NS was better than western medicine.

关 键 词：全肺灌洗 矽肺 动物模型 病理 

分 类 号：R135.2[医药卫生—劳动卫生] R－332[医药卫生—公共卫生与预防医学]