口服二巯基丁二酸治疗狗路易氏剂中毒  

Oral administration of dimercaptosuccinic acid in the treatment of lewisite intoxication

作　　者：张理汉[1] 闻思真[1] 杨进生[1] 沈伽弟[1] 

机构地区：[1]军事医学科学院毒物药物研究所

出　　处：《军事医学科学院院刊》1997年第1期39-42,共4页Bulletin of the Academy of Military Medical Sciences

摘　　要：为证实口服二巯基丁二酸（ＤＭＳＡ）治疗路易氏剂中毒的效价，以狗为实验动物，进行实验治疗研究。狗口服ＤＭＳＡ（４０～１２０ｍｇ／ｋｇ）后，２周内未见到有关的生理、生化指标明显变化，该药毒性较小。ＤＭＳＡ可在肠道内较好地被吸收，与静脉注射途径比较，口服组血药浓度上升慢，下降亦慢，可在体内维持较长时间。ＤＭＳＡ在体内促排砷的作用与静脉注射同剂量ＤＭＳＡ（钠盐）相当。狗口服ＤＭＳＡ４０ｍｇ／ｋｇ可对抗路易氏剂１个致死量中毒，其效价与静脉注射同剂量ＤＭＳＡ（钠盐）相当。以上结果证明，口服ＤＭＳＡ可以代替静脉注射途径给药对抗路易氏剂中毒，作者推荐的人用剂量为口服每次２ｇ／人，每日２次。To confirm the antidotal action of dimercaptosuccinic acid (DMSA) against lewisite intoxication, a study on experimental therapy in dogs was carried out. After oral doses of DMSA (40-120 mg/kg), no apparent physiological or biochemical changes could be seen, indicating that this drug had quite low toxicity. It could be absorbed in the intestinal tract. After oral administration, the blood level of DMSA rose more slowly, dropped more slowly, and was maintained for a longer period as compared with that after intravenous injection. An oral dose of DMSA (40 mg/kg) could antagonize one lethal dose of lewisite intoxication in dogs. Such effectiveness could be compared to the same dose level of DMS Na given intravenously. It could promote the arsenic excretion just similar to the intravenous route. These results show that intravenous DMS Na may be replaced by oral DMSA to antagonize the lewisite intoxication. The authors recommend the oral dose of DMSA in human to be 2 g twice daily.

关 键 词：路易氏剂 二巯基丁二酸 药代动力学 砷 解毒剂 

分 类 号：R827.170.5[医药卫生—临床医学] R979.3