肝炎患者血清中瘦素测定的临床价值探讨  

Evaluation of the clinical value of the concentration of leptin in viral hepatitis

作　　者：李瑞炎[1] 熊金虎[1] 

机构地区：[1]武汉大学中南医院,湖北武汉430071

出　　处：《临床肝胆病杂志》2007年第2期96-97,共2页Journal of Clinical Hepatology

摘　　要：探讨不同病毒性肝炎患者血清中瘦素水平的改变及临床价值。采用竞争ELISA法分析检测162例不同类型的病毒性肝炎患者及78例正常健康人血清中瘦素,动态观察并进行分析、比较。162例各类型肝炎患者的血清中瘦素均值为(15.66±3.16)ng/L,正常对照值为(6.46±3.18)ng/L,两者相比差异有统计学意义(P<0.01),而各型病毒肝炎患者中的血清瘦素浓度随着病情程度的逐步恶化而升高。选择42例病毒性肝炎患者进行血清瘦素动态观察,发现治疗前后有统计学意义(P<0.01)。血清中瘦素的测定,有可能作为病毒性肝炎患者转归程度判断的一个指标。To observe the relationship between the concentration of leptin and viral hepatitis. In a period of time, 162 cases with several kinds of viral hepatitis and 78 cases of normal control have been detected and analyzed for the concentration of leptin using competitive ELISA. The results showed that the concentration of leptin in serum from the patients with viral hepatitis was 15.66 -± 3. 16ng/L which was highly distinct from that of the normal control （ 6. 46 ± 3. 18ng/L） （ P 〈 0. 01 ）. The level of the leptin was associated with the course of the disease, and increasd with the progressing of disease. The dynamic study of the concentration of leptin of 42 patients showed that there was a statistic distinction in the cases of pre - cure comparing with that of after - cure （ P 〈 0. 01 ）. So the concentration of leptin might be a candidate index for evaluating the progresses of viral hepatitis patients.

关 键 词：肝炎 瘦素 ELISA法 

分 类 号：R512.6[医药卫生—内科学]