徐州地区汉族人及慢性乙型肝炎HLA-A基因多态性的研究  

The relationship between HLA-A alleles polymorphism and susceptibility to HBV in the Han nationality in Xuzhou

作　　者：戴玮玮[1] 陈明[1] 汪莉萍[1] 孙海丰[2] 傅涓涓[1] 李秀华[1] 

机构地区：[1]徐州医学院附属医院感染病科,江苏221002 [2]丰县人民医院感染病科,江苏丰县221700

出　　处：《临床肝胆病杂志》2007年第2期100-102,共3页Journal of Clinical Hepatology

基　　金：江苏省科委社会发展基金资助(BS2004014)

摘　　要：探讨慢性乙型肝炎与HLA-A位点的等位基因多态性。用PCR-SSP方法对徐州地区汉族正常组和慢性乙型肝炎组的HLA-A基因多态性进行分析。HLA-A*0201-17出现的频率在慢性乙型肝炎组为45.57%,高于正常组的29.69%,P=0.002<0.05,RR=1.983,(95%C I:1.227-3.080),具有统计学意义。HLA-A*0201-17与慢性乙型肝炎较高的相关性,可能为易感基因。To investigate the relationship between HLA- A alleles polymorphism and susceptibility to HBV in the Han nationality in Xuzhou. Typing HLA - A genotype was performed by using PCR - SSP （ polymerase chain reaction - sequence specific primers technique） in seventy - nine patients with hepatitis B and ninty - six healthy people in Xuzhou of China. The frequency of HLA -A .0201 -0217 allele was 45.57% in patient group, which was higher than that （29. 69% ） of the normal healthy people （ s^2 = 9. 394, P 〈 0. 05, RR = 1. 983, 95% CI ： 1. 227 - 3. 080）. The susceptibility to chronic hepatitis B might be strongly associated with HLA - A ＊ 0201 -0217 allele of Chinese patients in Xuzhou.

关 键 词：乙型肝炎 疾病易感性 人类白细胞抗原 序列特异性引物聚合酶链反应 

分 类 号：R512.62[医药卫生—内科学]