Baculoviruses as Vectors in Mammalian Cells  

作　　者：Chang-yong LIANG Xin-wen CHEN 

机构地区：[1]State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071,China

出　　处：《中国病毒学》2007年第2期148-157,共10页Virologica Sinica

基　　金：National Nature Science Foundations of China (30325002, 30470075)

摘　　要：The Baculoviridae are a large family of enveloped DNA viruses exclusively pathogenic to arthropods. Baculoviruses have been extensively used in insect cell-based recombinant protein expression system and as biological pesticides. They have been deomostrated to be safe to mammals, birds and fish. Recently, baculoviruses has been shown to transduce different mammalian cells in spite of the fact that they cannot replicate in mammalian cells (11, 73, 76). This has resulted in the development of baculoviruses as mammalian expression systems and even as vestors for gene therapy.The Baculoviridae are a large family of enveloped DNA viruses exclusively pathogenic to arthropods. Baculoviruses have been extensively used in insect cell-based recombinant protein expression system and as biological pesticides. They have been deomostrated to be safe to mammals, birds and fish. Recently, baculoviruses has been shown to transduce different mammalian cells in spite of the fact that they cannot replicate in mammalian cells （11, 73, 76）. This has resulted in the development of baculoviruses as mammalian expression systems and even as vestors for gene therapy.

关 键 词：杆状病毒 哺乳动物 病毒细胞 医学研究 

分 类 号：R373[医药卫生—病原生物学]