电沉积HA-Ti／HA复合涂层及其生物学性能  

Biological Properties and Formation of Electrodeposited HA-Ti/HA Composite Coatings

作　　者：刘榕芳[1] 肖秀峰[1] 左友松[1] 唐晓恋[1] 高燕娇[1] 

机构地区：[1]福建师范大学化学与材料学院,福州350007

出　　处：《生物医学工程学杂志》2007年第2期350-355,共6页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(30600149);卫生部科学研究基金-福建省卫生教育联合攻关计划资助项目(2005-02-008);福建省发改委资助项目[2004]477

摘　　要：为了提高HA涂层的结合强度,采用两步电沉积法制备HA-Ti／HA复合涂层,对涂层的组分结构、表面形貌和结合强度进行了研究,并对涂层进行模拟体液和体外细胞实验,以考察涂层的生物学性能。实验结果表明: HA-Ti／HA复合涂层的结合强度明显高于HA涂层,当涂层中Ti的质量分数为51．2 wt％时,涂层与基体的结合强度达到21．2 MPa,约为纯HA涂层的3倍。涂层经模拟体液浸泡后,表面覆盖一层碳磷灰石(Carbonate-apatite),表明涂层具有良好的生物活性。体外细胞实验表明,骨髓基质细胞能在涂层表面黏附繁殖生长,表明涂层具有良好的生物相容性。In order to improve the bonding strength of the hydroxyapatite （HA） coatings on the metal substrate, we prepared the HA-Ti/HA composite coatings by two-step electrodeposited method, and then we studied the component, microstructure, surface morphologies and the bonding strength of the HA-Ti/HA composite coatings. SBF test and cell culture in vitro were carried out to evaluate the biological properties of the composite coatings. The results showed that the bonding strength of the HA-Ti/HA composite coating （Ti, 51.2wt%） was as high as 21.2 MPa which was ：3 times that of pure HA coatings. The coatings＇ surface was covered by carbonate-apatite layer after being immersed in SBF, and the bone marrow cells attached firmly and proliferated well on the surface of composite coatings. These findings indicate that the composite coatings possess good bioactivity and excellent biocompatibility.

关 键 词：羟基磷灰石 电沉积 模拟体液 细胞培养 

分 类 号：R318.08[医药卫生—生物医学工程]