利用不同成孔剂制备快速响应型pH敏感水凝胶  

Preparation of Fast Responsive, pH Sensitive Polyacrylic Acid Gel with Different Pore-forming Agents

作　　者：张艳[1] 谭天伟[1] 

机构地区：[1]北京大学生命科学与技术学院,北京100029

出　　处：《生物医学工程学杂志》2007年第2期363-367,共5页Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(20136020)(50373003)(20325622);北京市自然基金资助项目(2032013);博士点基金资助项目(20030010004)

摘　　要：本实验利用5种成孔剂制备了可用作泪点栓子材料的快速响应型pH敏感聚丙烯酸凝胶,这五种成孔剂分别是聚乙二醇400(PEG-400)、壳聚糖、壳聚糖明胶聚合物、CaCO3和Na2CO3。试验测定了添加成孔剂对凝胶溶胀速率的影响,并讨论了各种成孔剂的作用机理及效果,最后研究了作用效果较好的三种成孔剂添加量对凝胶溶胀速率即溶胀比的影响。结果证明PEG-400作用效果最好,使凝胶在5 min左右即可完成95％以上的形变,在30 ml的体系里PEG-400、聚合物及Na2CO3的最适添加量分别为1、0．8、1 ml,可以满足用做泪点栓子材料的要求。Five kinds of pore-forming agents, including PEG-400, chitosan, the polymer of chitosan and glutin, CaCO3 and Na2CO3, were used in this experiment to prepare fast responsive and pH sensitive Polyacrylic acid （PAAc） gel which could be used as the material of punctum plug. The mechanism and effects of pore-forming agents on PAAc gel were studied; besides, the experiment also assessed the effects of the three most effective pore-forming agents on gel＇s water retention and swelling rate. The results showed that the most suitable dose levels of PEG-400, the polymer and NazCO3 were 1 ml, 0.8 ml and 1 ml respectively, and PEG-400 was most effective with the same dosage; the gel with PEG-400 as pore-forming agent could finish more than 95% of the swelling process in just 5 minutes, it is suitable for use as punctum plug material.

关 键 词：成孔剂 聚丙烯酸 水凝胶 响应速率 

分 类 号：R319.08[医药卫生—基础医学]