硝石矾石散对免疫性肝损伤小鼠肝脏病理的影响  

Effects of Xiaoshi Fanshi Powder on Hepatic Pathological Damage Caused by Immune Hepatic Injury Model in Mice

作　　者：张秋霞[1] 赵晖[1] 于楠[1] 闫晓媛[1] 徐萌[1] 薛璞[1] 

机构地区：[1]首都医科大学中医药学院

出　　处：《首都医科大学学报》2007年第2期200-202,共3页Journal of Capital Medical University

基　　金：北京市2004年优秀人才基金资助

摘　　要：目的研究不同药物组成的硝石矾石散对免疫性肝损伤小鼠肝脏病理的影响。方法采用数字表法将动物分为正常组、模型组、火硝白矾组、火硝绿矾组、芒硝白矾组、芒硝绿矾组和联苯双酯阳性对照组7组。制作卡介苗(BCG)和脂多糖(LPS)诱导的小鼠免疫性肝损伤模型,观察各组药物对模型动物肝脏病理学改变的影响。结果和模型组相比,火硝白矾组小鼠的肝脏病理损伤减轻。结论火硝白矾组对免疫性肝损伤模型有很好的保护作用。Objective To study the effects of different xiaoshi Fanshi Powders which consist of different components on hepatic pathological damage caused immune hepatic injury in mice. Methods Firstly, ICL mice were selected and randomized into seven groups： normal control group, model group, Huoxiao Baifan group, Huoxiao Lufan group, Mangxiao Baifan group, MangxiaoLufan group, and bifenbate group. Secondly, one day after intravenous injection of BCG, the equal amount of saline was given for gastric perfusion to the normal control group and model group. The corresponding medicines were given for gastric perfusion to the other groups. At last, The liver was reserved for routine light microscopy so as to determine the pathological damage degree of liver tissue. Results Huoxiao Baifan group could alleviate pathological damage of liver tissue in mice. Conclusion These results suggest that Huoxiao Baifan powder has a markedly protective effect on immune hepatic injury in mice.

关 键 词：免疫性肝损伤 卡介苗 脂多糖 

分 类 号：R392.3[医药卫生—免疫学]