出生前氚水照射致大鼠脑细胞缺失的剂量效应关系研究  

STUDY ON DOSE-RESPONSE RALATIONSHIP BETWEEN PRENATAL EXPOSURE TO TRITIATED WATER (HTO) AND LOSS OF THE CEREBRAL CELLS IN RATS

作　　者：杨志远[1] 郭月凤[1] 

机构地区：[1]中国辐射防护研究院

出　　处：《辐射防护》1990年第4期255-258,266,共5页Radiation Protection

摘　　要：将妊娠11天的大鼠经腹腔单次注入3.70×100~4—5.55×10~6Bq/mL(体水)氚水,仔鼠出生18天后开颅取出仔鼠大脑组织,制成脑组织切片,观察大脑皮质第Ⅴ层锥体细胞数的变化。结果表明,仔鼠大脑锥体细胞数随剂量的增加而显著减少(p<0.01);在仔鼠总吸收剂量为0.012—1.7Gy范围内,大脑锥体细胞缺失率Y(％)与剂量D(Gy)可拟合成对数直线回归方程Y=27.1+8.311gD。A single intraperitoneall injection of HTO into rats at the 11th day of gestation which resulted in the absorbed dose as: low as 0.012Gy might induce a signifieant decrease in the number of the cerebralpyramical cells in their 18-day-old offsprings. The percentage of thedecrease in number of the cerebral pyramidal cells was positively relatedto the logarithm of doses at the range of 0.012-1.7Gy. The correlationcoefficient was 0.962 (p<0.01) and the relationship between the decreaseof percentage (Y,%) and the absorbed dose (D, Gy) gave a good fit to alinear regression equationY=8.311gD+27.1

关 键 词：氚水 脑细胞 缺失 剂量效应 大鼠 

分 类 号：R811.5[医药卫生—放射医学]