适合MRI评价的兔脑缺血再灌注模型  

Establishment of Rabbit Model of Cerebral Ischemia-reperfusion with MRI

作　　者：杨冀萍[1] 刘怀军[1] 张聪敏[2] 李林芳[1] 吴雅丽[2] 

机构地区：[1]河北医科大学第二医院医学影像科,石家庄050000 [2]河北医科大学第二医院呼吸内科,石家庄050000

出　　处：《放射学实践》2007年第4期348-349,共2页Radiologic Practice

摘　　要：目的建立适合MRI评价的脑缺血再灌注模型。方法雄性新西兰白兔51只,随机分成对照组(n=3)、假手术组(n=8)和再灌注组(n=40)。应用导丝造成大脑中动脉血供阻断(MCAO)2h,于再灌注各时间点对动物进行行为评分、MRI及形态学评价。结果再灌注组表现为左侧大脑半球颞顶叶及外侧基底节区域T2WI、DWI高信号,并随再灌注时间延长逐渐增大,3天后减小。结论采用该方法能够建立适合MRI评价脑缺血再灌注模型,是进一步研究的基础。Objective：To establish a model of cerebral ischemia-reperfusion in rabbits with MRi. Methods.. Fifty-one male New Zealand white rabbits were randomly divided into control （n= 3）,sham-operated （n= 8）, reperfusion group （n= 40） ,in which the occlusion of left middle cerebral artery was induced by guide wire for 2 hours. At different reperfusion points,MR scanning,neurological deficit score and gross anatomy were carried out. Results.. High signal was seen on DWI and T2 WI, which was enlarged with the time and decreased after 3 days. Conclusion.. A model of ischemia-reperfusion with MRI can be set up by using this method. It lays a foundation for further study.

关 键 词：脑缺血 磁共振成像 再灌注损伤 模型 动物 

分 类 号：R445.2[医药卫生—影像医学与核医学]