五灵脂萃取物对实验性胃溃疡及胃酸分泌的作用  

EFFECT OF FAECES TROGOPTERORI EXTRACT ON EXPERIMENTAL GASTRIC ULCER AND GASTRIC SECRETION IN RAT

作　　者：程志安[1] 李庆明[1] 王雄文[1] 

机构地区：[1]中山医科大学孙逸仙纪念医院中医科

出　　处：《中山医科大学学报》1997年第1期47-50,共4页Academic Journal of Sun Yat-sen University of Medical Sciences

基　　金：国家自然科学基金

摘　　要：五灵脂（简称ＷＬＺ）经加工后萃取出４个部分：ＷＬＺ－Ａ、Ｂ、Ｃ、Ｄ，用Ｓｈａｙ模型和利血平模型研究五灵脂保护胃粘膜作用的有效成分及其作用机制。实验结果：ＷＬＺ－Ｂ组的胃液量、胃酸酸度和总分泌量均少于空白对照组（Ｐ＜０．０１），而且存在量效关系；两种模型ＷＬＺ－Ｂ组的粘膜损伤指数均小于空白对照组（Ｐ＜０．０１）。表明ＷＬＺ－Ｂ具有抑制胃酸分泌，保护胃粘膜，预防实验性胃溃疡的作用。Four components from faeces trogopterori (WLZ) extract: WLZ A, B, C,D were isolated for elucidating the protective effect of which on gastric mucosa and identifying the effective principle. Shay model and reserpine model were used. The results showed that the amount of gastric juice, gastric acidity and total secreting acid of WLZ B groups were significantly lower than that of the control group ( P <0.01). The lesion scores of WLZ B groups in both models were significantly lower compared with control groups ( P <0.01). These results indicate that the mechanism by which the WLZ B protect mucosa and prevent ulceration is due to inhibition of the gastric secrection.

关 键 词：五灵脂 药理学 胃酸分泌 胃溃疡 中医药疗法 

分 类 号：R259.731[医药卫生—中西医结合] R285.5[医药卫生—中医内科学]