氨茶碱治疗胎儿窘迫的探讨  

EVALUATION ON THE EFFECT OF AMINOPHYLLINE ON FETAL DISTRESS

作　　者：王蕴慧[1] 梅少芬[1] 丁红[1] 

机构地区：[1]中山医科大学孙逸仙纪念医院妇产科

出　　处：《中山医科大学学报》1997年第1期59-61,67,共4页Academic Journal of Sun Yat-sen University of Medical Sciences

摘　　要：将胎儿窘迫６０例随机分为甲、乙两组，每组３０例。甲组给予氨茶碱０．２５ｇ加入葡萄糖液缓慢静脉推注，乙组用维生素Ｃ、维生素Ｋ１加入葡萄糖液静脉推注。用药前后观察胎心情况、羊水情况，新生儿出生后行脐血血气分析及新生儿Ａｐｇａｒ评分。结果显示：用药后甲组胎心改善率为７９％，乙组为４８％（Ｐ＜０．０５）；血ｐＨ＜７．２者，甲组为２５％，乙组为４２％；平均ＰＣＯ２甲组为５．９８％ｋＰａ，乙组为７．５７ｋＰａ（Ｐ＜０．００１）；新生儿Ａｐ－ｇａｒ评分≤７者，甲组为２／３０，乙组为１０／３０（Ｐ＜０．０５），提示用氨茶碱进行胎儿宫内复苏是有效的。To investigate the effect of aminophylline on fetal distress, sixty cases of pregnancy with fetal distress were devided at random into two groups. In one group(group A), 0.25g of aminophylline combined with 50% glucose was administrated intravenously. In another group (group B), 0.5g of vitamin C, 10mg of vitamin K 1 and 50% glucose were used intravenously. Changes of fetal heart rate, amniotic fluid, blood gas assaying of umbilical veins and newborn Apgar score in two groups were evaluated. Improved heart rate was 79% in group A and 48% in group B after administration of the medicines( P <0.05). Blood pH lower or equal to 7.2 based on blood gas assaying was 25% in group A and 42% in group B. Mean value of PCO 2 was 5.98 kPa in group A and 7.57 kPa in group B ( P <0.01). Newborn Apgar score equal to or lower than 7 in group A (2/30) was significantly lower than that in group B(10/30)( P <0.05). Aminophylline is effective for the resuscitation of intrauterine fetal distress.

关 键 词：氨茶碱 胎儿窘迫 新生儿窒息 

分 类 号：R714.43[医药卫生—妇产科学] R722.120.5[医药卫生—临床医学]