孕期高同型半胱氨酸、缺锌与先天性心脏病  

Relationship between maternal homocysteinemia,zinc deficiency in pregnancy and congenital heart disease of the fetus

作　　者：曾芳[1] 何晓宇[1] 

机构地区：[1]福建医科大学福总临床医学院妇产科,福建福州350025

出　　处：《中国妇幼健康研究》2007年第2期129-131,共3页Chinese Journal of Woman and Child Health Research

摘　　要：先天性心脏病是指胎儿在出生以前由于心血管发育障碍所导致的心血管系统的形态结构、功能及代谢异常。该病发病率较高,临床后果严重。研究其发病因素及机制具有重要意义。孕期环境因素的改变对其有重要影响。近期孕妇高同型半胱氨酸血症与缺锌已被确定均能干扰胚胎心脏正常发育,导致先天性心脏病的发生。该文就两者引起胚心异常发育的表现及作用机制进行综述。The definition of congenital heart disease is antenatal abnormalities in morphology, structure, function and metabolism of the fetuses caused by abnormal development of cardiovascular system in fetal period. The disease has a high incidence and poor prognosis. The study on etiology and pathogenesis is of very important significance. The alteration in environmental factors during pregnancy has a significant influence on development of the disease. It is thought that homocysteinemia and zinc deficiency in pregnancy may interfere with normal development of fetal heart, which leads to development of congenital heart disease. This article reviewed types and presentations of abnormal development of fetal heart caused by these two factors and their possible mechanisms.

关 键 词：先天性心脏病 高同型半胱氨酸 锌缺乏 胚胎发育 

分 类 号：R541.1[医药卫生—心血管疾病] R714.14[医药卫生—内科学]