T细胞疫苗诱导同种移植物存活期延长  

PROLONGATION OF CARDIAC ALLOGRAFT SURVIVAL BY T CELL VACCINATION

作　　者：陈永良[1] 何球藻[1] 

机构地区：[1]上海医科大学免疫学教研室

出　　处：《中国免疫学杂志》1997年第1期40-44,共5页Chinese Journal of Immunology

摘　　要：以同种细胞体内免疫小鼠，取免疫脾细胞经体外低剂量ＣｏｎＡ培养扩增后，用戊二醛灭活法制备Ｔ细胞疫苗，然后以此免疫同系正常小鼠，观察小鼠同种心肌移植物存活时间的改变。Ｔ细胞疫苗免疫组移植物存活时间显著延长，与正常对照组比较Ｐ＜０．００１；但发现在Ｔ细胞疫苗免疫组中，与用于免疫制备Ｔ细胞疫苗同一来源的移植物存活期又比无关来源的同种移植物存活期显著延长，而后者与抗原非特异活化Ｔ细胞免疫组比较无显著差异。结果表明：Ｔ细胞疫苗免疫可以诱导抗原特异和抗原非特异双重作用的免疫低反应性，提高同种移植物的存活率。In recent studies,administration of attenuated,activated autoimmune T lymphocytes to syngeneic mice or rats has been showed to prevent or induce remission of experimental autoimmune disease.The process has been termed “T cell vaccination”.The present study was undertaken to observe whether T cell vaccination can induce hyporeactivity to alloantigen in vivo in mice.The results showed that vaccinating mice with syngeneic,activated in vitro by ConA,alloantigen primed in vivo T lymphocytes significantly induced the prolongation of cardiac allograft survival.The phenominon had the feature of both antigen and non antigen specifity,because,although the prolongation of both grafts from the same strain of developing T cell vaccination and any third party,former was much longer than later.

关 键 词：T细胞疫苗 同种移植 移植物 存活率 

分 类 号：R392.4[医药卫生—免疫学]