一氧化氮代谢产物测定在支气管哮喘的临床意义  

CLINICAL SIGNIFICANCE OF METABOLIC PRODUCTS OF NITRIC OXIDE IN BRONCHIAL ASTHMA

作　　者：张遵一[1,2] 田亚平[1,2] 王成彬[1,2] 李涛[1,2] 李纪选 

机构地区：[1]解放军总医院 [2]解放军总医院生化科

出　　处：《中国免疫学杂志》1997年第1期52-53,共2页Chinese Journal of Immunology

摘　　要：应用亚硝酸盐法对支气管哮喘患者进行一氧化氮代谢产物的测定，采用化学发光法测白细胞氧化活性。结果显示哮喘患者体液中一氧化氮代谢产物为３．４３±０．５３μｍｏｌ／Ｌ，明显高于正常组１．０２９±０．３３８９μｍｏｌ／Ｌ，差异非常显著Ｐ＜０．０１。白细胞氧化活性为３９．９０±４．１２ｍｖ明显高于正常对照组１２．９３±３．１６ｍｖ，Ｐ＜０．０１，差异非常显著。结果提示一氧化氮可能参与哮喘的炎症反应。一氧化氮测定对了解病情程度，评价疗效及探讨哮喘的发病机理有一定价值。Metabolic products of nitric oxide were measured by nitrite reduction test and leukocyt oxidizing activity was assayed by chemiluminescence in patients with brochial asthma.The results showed that matabolic products of nitric oxide was 3.43±0.53 μmol/L in patiets with asthma higher than 1.0291±0.3389 μmol/L in control group (P<0 01).Leukocyte oxidizing activity was 39.90±4.12 mv in patients with asthma higher than 12.93±3.16 mv in control group (P<0 01).It was suggested that nitric oxide may participate inflammatory reaction in patients with asthma.Assay of nitric oxide is worthy in estimating severity,therapeutic evaluation and pathogenesis in patients with asthma.

关 键 词：哮喘 一氧化氮 白细胞氧化活性 

分 类 号：R562.25[医药卫生—呼吸系统]