不稳定型心绞痛患者冠脉循环与周围血中纤维蛋白原和D-二聚体的变化  

The Changes of Fibrinogen and D-Dimer in General Circulation and Coronary Circulation of Patients With Unstable Angina Pectoris

作　　者：任爱平[1] 陈宁[1] 王蒙琴[1] 杨叶[1] 

机构地区：[1]包头医学院第一附属医院急诊科,内蒙古包头014010

出　　处：《内蒙古医学杂志》2007年第3期285-287,共3页Inner Mongolia Medical Journal

摘　　要：目的:了解不稳定型心绞痛(UAP)患者冠脉循环和周围血中纤维蛋白原(Fg)和D-二聚体(DD)的变化。方法:选32例UAP患者和10例冠脉造影无狭窄的正常人为研究对象。在做冠脉造影时同时采集冠状静脉窦(CS)、主动脉根部(AO)和上腔静脉(SVC)血,测定DD和Fg含量。结果:UAP患者CS中Fg和DD含量均比正常人高。正常人和UAP患者三部位Fg、DD测定结果无明显差异。在心绞痛发病当时采血的UAP患者Fg、DD含量明显高于平均值,其CS中Fg含量比AO中低,DD含量比AO中高。结论:UAP患者存在凝血、纤维功能凝血的失调。UAP患者在心绞痛缓解后,冠脉循环中凝血、纤维状态与全身循环血中一致。心绞痛发作时,冠状动脉内有血栓生成并伴有纤溶活性改变。Objective： To assess the changes of D - Dimer （DD） and fibrinogen （Fg） in peripheral blood and coronary circulation of unstable angina peetoris.Methods：32 UAP patients and 15 control subjects with arteriographically normal coronary arteries were collected simulteaneously from eoronarysinus （CS）, aortic root （AO）, and superior vena eava（SVC）while coronary arteriography performed, plasma DD and Fg were analyzed. Rrsults： The levels of DD in CS, AO, and SVC were higer than that of control subjects. All these profiles did not differ in CS, AO, and SVC, either UAP patients or control subjects. Plasma concentration of Fg in CS of UAP patients who were having angina peetoris while samples withdrawn were lower, and plasma concentration of DD was higher than that in AO.Conclusion： The disorder of coagulation and fibrinolysis plays an important role in the pathogenesis of UAP. After acute phase, the state of coagulation and fibrinolysis in the coronary circulation of UAP patients is similar to that in peripheral blood, that is, peripheral blood samples may adequately reflect the activity of these markers in coronary circulation.

关 键 词：不稳定型心绞痛 纤维蛋白原 D-二聚体 

分 类 号：R541.42[医药卫生—心血管疾病]