急性心肌梗死冠脉成形术后内皮素-1的临床意义  

Clinical Meaning of Endothelin-1 In Acut Myocardidl Infarction Patients With PCI

作　　者：何涛[1] 

机构地区：[1]内蒙古自治区医院心内科,内蒙古呼和浩特010017

出　　处：《内蒙古医学杂志》2007年第3期290-292,共3页Inner Mongolia Medical Journal

摘　　要：目的:探讨急性心肌梗死(AMI)病人血浆内皮素-1(ET-1)的浓度与临床结果(包括死亡率)及左心室(LV)收缩功能的关系。方法:本研究包括110例初次AMI的病人,成功的进行了冠脉再灌注,血浆ET-1浓度从发作开始连续监测24h。病人根据中间值分为2组,高组(≥2.90pg/ml,n=55)及低组(<2.90pg/ml,n=55)。两组的主要并发症及LV收缩功能均进行监测。结果:ET-1与高敏C反应蛋白(hs-CRP)和脑钠肽(BNP)有相关性。慢性阶段左室射血分数(LVEF)和左室舒张未容积指数(LVEDVI)在高组明显降低。在高组出现并发症明显高于低组。结论:在AMI阶段,血浆ET-1的浓度可能与左室收缩功能有关,可导致预后差,包括死亡率。Objective： The aim of the present study was to investigate the relationship between plasma concentrations of endothelin （ET） - 1 and clinical outcome （including mortality） and left ventricular （LV） systolic function in acute myocardial infarction （AMI）. Methods： The study group comprised 110 consecutive first- AMI patients who were successfully reperfused by primary coronary intervention. Plasma ET- 1 concentrations were evaluated 24h from onset and the patients were divided into 2 groups according to the median value, either a high group （Hgroup： ≥2.90pg/ml plasma ET - 1 ; n = 55 ） or low group （ L group： 〈 2.90pg/ml plasma ET - 1;n = 55）, Major complications and LV systolic function were monitored in the 2 groups. Results： Both highly sensitive C- reactive protein （hs - CRP） and brain natriuretic peptide （BNP）, showed a significant positive correlation with ET- 1. Chronic stage left ventricular ejection fraction （LVEF） and left ventricular end- diastolic volume index （LVEDVI） were significantly poorer in the H group. There were significantly more major comp lications in the H group than in the L group. Conclusions： In the setting of AMI, plasma ET - 1 concentrations may be closely related to LV systolic dysfunction and poor patient outcome, including mortality.

关 键 词：内皮素 急性心肌梗死 预后 心室功能 

分 类 号：R542.22[医药卫生—心血管疾病]