局部接触振动家兔血清某些指标变化的实验研究  

Experimental study on the concentrations of IL-8 and TXB_2 in local vibration rabbits

作　　者：于永胜[1] 林立[1] 张春之[1] 马海燕[1] 

机构地区：[1]济宁医学院职业卫生与环境医学重点实验室,山东济宁272013

出　　处：《中国职业医学》2007年第2期110-111,114,共3页China Occupational Medicine

基　　金：山东省自然科学基金资助课题(Y2002c20)

摘　　要：目的探讨局部接触振动(简称接振)家兔血清白细胞介素-8(IL-8)及血浆血栓烷素B2(TXB2)浓度的变化趋势及其意义。方法24只家兔随机分为接振组(又分为低剂量A组3.03m/s2、中剂量B组6.13m/s2、高剂量C组12.30m/s2)和无接振对照D组。接振组接振45d,分别于接振实验前、接振第15、30、45天经耳中动脉采血,用放射免疫法测其血清IL-8及血浆TXB2浓度。结果①与接振前比较,低剂量组IL-8浓度第30、45天明显降低,差异有显著性(P<0.05,P<0.01);中、高剂量组第15、30、45天血清IL-8浓度显著降低(P<0.01);与对照组比较,接振第15天中、高剂量组血清IL-8浓度降低有意义(P<0.05,P<0.01);接振第30天高剂量组血清IL-8浓度降低有显著性;而第45天各组血清IL-8浓度降低均有显著性(P<0.01)。②与接振前比较,3个实验组接振后各个时间的TXB2浓度均较实验前增高,差异具有显著性(P<0.05,P<0.01);与对照组比较,接振后TXB2浓度明显上升(P<0.05,P<0.01)。结论局部振动可导致家兔血清IL-8浓度的降低,及血浆TXB2浓度的升高,两者的变化可能与手臂振动病的发病有一定关系。Objective To investigate the impact of local vibration on the concentrations of IL-8 and TXB2 in rabbits and to explore their meaning. Methods 24 rabbits were divided randomly into four groups. Three groups were tested with different vibration power （group A 3.03 m/s^2 ,group B 6. 13 m/s^2, group C 12. 30 m/s^2） and one was tested as the normal control group. Serum levels of IL-8 and TXB2 were measured with radioimmunoassay. Results IL-8 concentrations in three vibration groups were significantly decreased compared with those in the controls （P 〈 0. 05, P 〈 0. 01 ）, however, the level of TXB2 was significantly higher than that of the controls （P 〈 0. 05, P 〈 0.01 ）. Conclusion Local vibration may cause serum level of IL-8 decrease and level of TXB2 increase. These changes may relate to the pathogenesis of hand arm vibration disease.

关 键 词：局部振动 白细胞介素-8 血栓烷素B 

分 类 号：R135.4[医药卫生—劳动卫生]