2004至2005年我院嗜血杆菌的分离及其耐药性  

Isolation rate and drug resistance of Haemophilus during 2004～2005 in our hospital

作　　者：吴春凤[1] 姜焕好[2] 曾东良[1] 叶莉[2] 叶国强[1] 

机构地区：[1]深圳市宝安人民医院检验科,广东深圳518101 [2]深圳市宝安人民医院呼吸内科,广东深圳518101

出　　处：《中国微生态学杂志》2007年第1期78-79,共2页Chinese Journal of Microecology

摘　　要：目的了解我院2004至2005年流感嗜血杆菌的分离率、产酶率,并对其耐药性进行分析,指导临床合理用药控制嗜血杆菌的流行。方法对1695份痰及咽拭子标本进行嗜血杆菌分离培养、鉴定,并用头孢硝噻吩纸片法进行β-内酰胺酶测定,采用琼脂扩散法进行药敏试验。结果共分离出226株嗜血杆菌,其中流感嗜血杆菌52株,副流感嗜血杆菌174株。产β-内酰胺酶42株,对氨苄西林、复方新诺明、环丙沙星的耐药率分别为22.1%、74.3%和57.5%。而对阿莫西林/棒酸、阿奇霉素、头孢噻肟、头孢呋辛钠、亚胺培南、利福平、氨曲南的耐药率均低于10%。结论我院呼吸道嗜血杆菌感染以副流感嗜血杆菌为主,临床上治疗嗜血杆菌感染最有效的药物是头孢噻肟。Objectives To investigate the isolation rate ,enzyme-producing rate and drug resistance of Haemophilus infuenzae and Haemophilus prarinfluenzae during 2004 - 2005 in our hospital And to provide a resistance analysis for the guidance of treatment of Haemophilus species infection. Methods Haemophilus from 1695 sputa and throat swabs were isolated and identifed. The β-lactamases producing rate was examined by nitrocefin. Drug resistance of Haemophibus was examined by K-B method. Results Of 226 Haemophilus species, 52 were Haemophilus infulenzae, and 174 were Haemophilus parainfulenzae. And 42 were β-lactamases producing. The resistance rate of Ampicillin,Trimethoprim/Sulfa, Ciprofloxacin were 22.1%, 74.3 % and 57.5%. But the resistance rate of Amoxicillin/Clavulanic, Azithromycin, Cefotaxime, Cefuroxime sodium, Imipem, Rifampin,Aztreonam were under 10%. Conclusions Haemophilus parainfluenzae was the main infection in person with respiratory tract infection in our hospital. Cefotaxine was the most effective antibiotics for Hsemophilus species infection.

关 键 词：呼吸道感染 嗜血杆菌 耐药性 Β-内酰胺酶 

分 类 号：R378.4[医药卫生—病原生物学]