三七总皂苷缓释微球体外释药研究  

In Vitro Characterization of Saponins of Panax Notoginseng Micro-sphere as Sustained-release Systems

作　　者：张洪[1] 黄徐英[1] 

机构地区：[1]武汉大学人民医院药学部,湖北武汉430060

出　　处：《云南中医学院学报》2007年第2期10-13,共4页Journal of Yunnan University of Traditional Chinese Medicine

摘　　要：目的:寻找一种合适的三七总皂苷缓释微球的体外释放度测定方法。方法:采用直接释药法与透析释药法测定三七总皂苷缓释微球在pH=7.4的磷酸盐缓冲液与0.1mol.L-1的盐酸溶液中释放度。结果:直接释药法可反映微球的体外释放情况。结论:直接释药法是最适合模拟三七总皂苷缓释微球体外释放度的方法。Objective ： To search a proper method for the determination of in vitro release of saponins of panax notoginseng sustained- release micro- spheres. Methods： Immediate release and dialysis release methods were used to determine the in vitro release rate of aponins of panax notoginseng micro - spheres in pH = 7.4 buffer phosphate and 0. 1 mol ~ L- 1HCL solution. Results ： Immediate release method can reflect in vitro release of micro - spheres. Conclusion： Immediate release method is the best method to be used to determine the in vitro release of saponins of panax notoginseng from micro - spheres.

关 键 词：三七总皂苷 缓释微球 体外释放 

分 类 号：R285[医药卫生—中药学]