叶酸偶联白蛋白纳米粒的靶向性及药效评价  

Evaluation of Effect and Targetability on Folate-conjugated Albumin Nanoparticles

作　　者：刘海[1] 罗晓琴[2] 朱亮[2] 何练芹[2] 洪华云[2] 

机构地区：[1]南昌大学医学院药学系,江西南昌330006 [2]广东药学院药科学院,广东广州510006

出　　处：《广东药学院学报》2007年第1期50-52,共3页Academic Journal of Guangdong College of Pharmacy

基　　金：广东药学院科研基金项目(2005YKX06)

摘　　要：目的考察叶酸偶联白蛋白纳米粒(F-BSANP)的肿瘤靶向性并进行药效评价。方法采用直接注射法建立小鼠肝癌模型,肝癌小鼠分组进行体内分布及药效实验。结果包裹钙黄绿素的F-BSANP在肝癌小鼠肝脏中蓄积程度最高;而药效方面,包裹砒霜的F-BSANP组小鼠生存期最长。结论用叶酸偶联白蛋白纳米粒包裹药物能显著增强药物对肿瘤部位的靶向性,明显提高药效。Objective Inspect the effect and targetability on folate -conjugated albumin nanoparticles by animal experiment. Methods Making mouse liver tumor model with immediate injection method. , mice with liver tumor were divided into several groups for experiments of distribution and pharmacodynamics in vivo. Results Calcein level of liver tissue in the group of F-BSANP entrapping calcein was the highest in all groups; The living phase of mouse injected with F-BSANP entrapping arsenic trioxide is the longest. Conclusion F-BSANP entrapping drugs can significantly enhance the drugs to tumor sites and improve their efficacy.

关 键 词：叶酸 纳米粒 砒霜 靶向性 肝癌 

分 类 号：R96[医药卫生—药理学]