血浆纤维蛋白原与老年人周围动脉硬化闭塞性疾病的关系  

A Cross-sectional Study on the Relationship between Plasma Fibrinogen Level and the Peripheral Arterial Occlusive Disease

作　　者：朱善香[1] 何耀[1] 封康[1] 王洁 范利[3] 李小鹰[3] 

机构地区：[1]解放军总医院老年医学研究所流行病学研究室,北京100853 [2]总参通讯兵部门诊部,北京100039 [3]解放军总医院老年心内科,北京100853

出　　处：《中国慢性病预防与控制》2007年第2期113-116,共4页Chinese Journal of Prevention and Control of Chronic Diseases

基　　金：国家卫生部保健科研基金项目资助(20015006);北京市自然科学基金项目资助(7062063)

摘　　要：目的探讨血浆纤维蛋白原(Fbg)水平与老年人周围动脉硬化闭塞性疾病(PAOD)的关系。方法在北京市万寿路地区60岁及以上的居民中,整群随机抽取2680人,完成调查2334人(男943人,女1391人),由经过培训的调查员,采用面对面的方式进行调查和相关体检。Fbg的测定采用散射比浊法,正常值范围为200～400mg/dl。PAOD的诊断为有间歇性跛行(IC)症状或踝肱动脉压比值(AAI)<0.90。结果总人群Fbg水平为(412.6±111.3)mg/dl,男性(396.44±102.14)mg/dl,女性(423.57±115.84)mg/dl。经过多因素调整后,高Fbg组与正常组相比,其OR值(95%CI)为:男性1.41(0.96～2.06),女性1.16(0.89～1.52);合并后为1.24(1.00～1.55)。当按Fbg水平分为低(≤375.0mg/dl)、中(375.1～443.4mg/dl)、高(≥443.5mg/dl)组时,相对于低水平组,中、高水平组的OR值(95%CI)分别为:男性1.39(0.89～2.19),1.79(1.12～2.85);女性1.42(1.02～1.97),1.22(0.88～1.69)。结论血浆Fbg水平越高,PAOD患病危险性越大,提示控制Fbg水平对防治PAOD有一定意义。Objective To examine the relationship between the levels of plasma fibrinogen and the Peripheral Arterial Occlusive Disease （PAOD） in an elderly population. Methods A population-based cross-sectional study was conducted in an urban Beijing sample of 2 680 subjects aged 60 years or older. Plasma fibrinogen was measured by the means of dispersion and comparing turbidity. PAOD was assessed by symptoms of intermittent claudication （IC） as measured by the WHO/ROSE questionnaire and an ankle-arm systolic blood pressure index （AAI） （〈0.90）. Results （1）The mean of fibrinogen in the population were （396.44±102.14） mg/dl in men, （423.57±115.84） mg/dl in women and （412.6±111.3）mg/dl in total. （2） After adjusting for age, gender and other major factors, the odds ratios（OR） and 95% confidence intervals（95%CI） for high fibrinogen level group vs. normal group, the PAOD resulting from IC （＋） or AAI〈0.90 were 1.41 （0.96-2.06）in men and 1.16 （0.89-1.52）in women. When the fibrinogen level was divided for three groups of low, median and high, the 0R（95%CI） for the median vs. low level group werel.39 （0.89-2.19） in men and 1.42（1.02-1.97） in women. The corresponding 0R（95%CI） for high level group were 1.79 （1.12-2.85） in men and 1.22（0.88-1.69） in women. There was a dose-response relation between fibrinogen and increasing risk of PAOD. Conclusion High level of fibrinogen might be a major risk factor for PAOD in Chinese elderly.

关 键 词：周围动脉硬化闭塞性疾病 流行病学 血浆纤维蛋白原 

分 类 号：R541.4[医药卫生—心血管疾病]