纤维蛋白原、血尿酸与冠心病严重程度的关系  

The Relationship between Serum Fibrinogen,Uric Acid and the Severity of Coronary Artery Diseases

作　　者：马梅[1] 高雪梅[1] 何丽华[1] 孟东[1] 刘克强[1] 

机构地区：[1]天津市人民医院心脏中心,天津300121

出　　处：《中国慢性病预防与控制》2007年第2期117-119,共3页Chinese Journal of Prevention and Control of Chronic Diseases

摘　　要：目的探讨纤维蛋白原、血尿酸与冠心病严重程度的相关性。方法将156例行冠状动脉造影的患者按造影结果分为冠心病组和对照组,根据冠状动脉损害严重程度,用Leaman积分法进行评分。采用多因素分析方法探讨冠心病及Leaman积分与纤维蛋白原、血尿酸等因素的相关性。结果冠心病危险因素的Logistic回归分析显示,吸烟、年龄、纤维蛋白原、甘油三酯和低密度脂蛋白胆固醇与冠心病独立相关,其中纤维蛋白原的OR值及95%CI为5.53(2.08～14.70);性别、血尿酸等其他指标与冠心病相关性无统计学意义。冠状动脉Leaman积分的多元逐步回归分析显示,年龄、纤维蛋白原、总胆固醇、脂蛋白(a)和低密度脂蛋白胆固醇与冠状动脉积分独立相关,其中纤维蛋白原最为显著(t=4.70,P<0.001),而性别、血尿酸与冠状动脉积分相关性无统计学意义。结论纤维蛋白原为冠心病的独立危险因素之一,与冠心病严重程度独立相关。未发现血尿酸的水平增高是冠心病的独立危险因素。Objective To study the relationship between serum fibrinogen, uric acid and the severity of coronary heart disease （CHD）. Methods 156 patients with or without coronary heart disease were divided into CHD group and control group. All subjects were examined by cronary artery angiography. The severity of coronary artery stenosis was evaluated and graded with Leaman coronary scoring system. With the multiple analysis method, the relationships were studied between serum fibrinogen, uric acid and the severity of coronary heart disease. Results With multiple logistic regression, smoking, age, fibrinogen, triglyceride and low-density lipoprotein were independently associated with the severity of coronary heart disease. Gender, uric acid and other variables did not have significant independently association with the severity of coronary heart disease. With stepwise multiple regression analysis,age, fibrinogen, total cholesterol, lipoprotein （a） and low density cholesterol showed significant independent association with the severity of coronary heart disease, but uric acid and other variables did not. Conclusion Fibrinogen was related to the severity of coronary heart disease independently, but uric acid was not independently associated with the severity of coronary heart disease.

关 键 词：纤维蛋白原 尿酸 冠心病 LOGISTIC模型 Leaman积分系统 

分 类 号：R541.4[医药卫生—心血管疾病]