血清β2-微球蛋白与慢性肝炎疾病程度和病毒复制之间的关系  

Relationship of serum β2-microglobulin level with the degree of liver injury and serum viral load in patients with chronic hepatitis

作　　者：陆伟[1] 陈楠[1] 宋杰[1] 张沝[1] 张占卿[1] 

机构地区：[1]上海市（复旦大学附属）公共卫生临床中心,上海201508

出　　处：《世界感染杂志》2007年第2期133-134,140,共3页World Journal of Infection

摘　　要：目的探讨血清β2-微球蛋白（β2-MG）水平与慢性乙型肝炎血清HBV DNA滴度及临床类型之间的关系。方法对124例不同类型慢性乙型肝炎病人同时检测血清β2-MG和HBV DNA滴度，比较各临床类型和不同HBV DNA滴度的血清β2-MG水平。结果慢性乙型肝炎病人的血清β2-MG水平，慢性乙型肝炎重度〉中度〉轻度（P=0．000）；HBV DNA〉104拷贝／mL高于HBV DNA≤10^4拷贝／mL组（P=0．000）。结论慢性乙型肝炎病人血清β2-MG浓度水平能反映疾病的严重程度，并且和血清HBV DNA含量相关。Objective To explore the relationship of serum β2-microglobulin （β2-MG） level with HBV-DNA load in patients with chronic hepatitis B. Methods A total of 124 patients with different clinical types of chronic hepatitis B were divided into low replication group （serum HBV DNA≤ 10^4copies/mL） and high replication group （serum HBV DNA〉10^4 copies/mL）. Serum β2-MG in different clinical types and different serum viral loads were analyzed. Results Serum β2-MG level was highest in severe chronic hepatitis than that in moderate chronic hepatitis, and higher in moderate chronic hepatitis than mild chronic hepatitis （P=0.000）. Serum β2-MG level was higher in high replication group than that in low replication group （P=0.000）. Conclusion Serum β2-MG level is positively related with the degree of liver injury, and positively related with the serum viral load in chronic hepatitis B.

关 键 词：乙型肝炎 慢性 Β2-微球蛋白 HBV DNA滴度 

分 类 号：R512.62[医药卫生—内科学]