急性肺损伤患者血管内皮生长因子改变的意义  

Significance of Changes of Vascular Endothelium Growth Factor in Patients With Acute Lung Injury

作　　者：陈雯[1] 许国根[1] 陈颖[1] 缪群[1] 黄卫东[1] 

机构地区：[1]杭州市第一人民医院,杭州310006

出　　处：《内科急危重症杂志》2007年第2期74-75,共2页Journal of Critical Care In Internal Medicine

摘　　要：目的:观察急性肺损伤(ALI)患者血浆中血管内皮生长因子(VEGF)及相关指标的改变,并探讨其临床意义。方法:检测34例ALI患者多时间点血浆中VEGF、内皮素-1(ET-1)和循环内皮细胞(CEC)的含量,并设健康对照组。结果:ALI组入院当天血浆VEGF、EY-1和CEC均显著升高(P<0.01),并持续5d;血浆VEGF较早升高且幅度较大[入院当天(114.56±38.79)ng/L,入院第2天达高峰(137.38±49.94)ng/L,较对照组(42.32±14.51)ng/L显著增高(P<0.01)];并与其他指标有较好的相关性。结论:在治疗ALI时降低血浆中VEGF和ET-1的水平,有利于控制ALI患者的病情。Objective：To observe the plasma level of vascular endothelium growth factor （VEGF） and the related parameters in patients with acute lung injury （ALI） and to investigate its clinical s ignificance. Methods：VEGF, endothelin-1 （ET-1）, and circulating endothelial cell （CEC） values were measured respectively at various interval time in 34 patients diagnosed as ALl, whereas health persons were regarded as control group. Results： Plasma VEGF, ET-1, and CEC values were increased at the day of admission and lasted for 5 days （P〈0. 01）. Plasma VEGF value was （114. 56±38. 79） ng/L at the admission day, and （137. 38 ± 49. 94 ng/L） at the 2nd day of hospitalization, which was elevated earlier and higher than that in the control group （42. 32 ± 14. 51 ng/L） significantly （P〈0. 01）, and VEFG level was well correlated with the other parameters. Conclusions： It is beneficial to decrease the plasma VEGF and ET-1 for controlling the disease in patients with ALI during the treatment.

关 键 词：急性肺损伤 血管内皮生长因子 内皮素-1 内皮细胞 

分 类 号：R563[医药卫生—呼吸系统]