阿奇霉素的合成工艺研究  

Study on the Synthesis Route of Azithromycin

作　　者：张建州[1] 

机构地区：[1]郑州师范高等专科学校化学系,河南郑州450044

出　　处：《广州化工》2007年第2期34-36,共3页GuangZhou Chemical Industry

摘　　要：以红霉素6,9-亚胺醚为原料,采用硼氢化钾还原,以简单方法制备结晶9-脱氧-9a-氮杂-9a-同型红霉素A水合物,然后再将其甲基化得到阿奇霉素,收率为92%,并确定了还原反应的温度、时间、以及甲基化水解反应的试剂和催化剂。By using erythromycin 6 and 9-imino ether, a straightforward procedure was taken to obtain 9- deoxo-9a-aza-9a-homoerythromycin A that was methlated to obtain azithromycin with 92 % high field. Temperature of reducing reaction, time of reducing reaction, field of NaBH4 different mole equivalent, dissolvent of metlate hydrolyse reaction and catalyst of metlate hydrolyses reaction were ascertained.

关 键 词：阿奇霉素 红霉素6 9-亚胺醚 结晶9-脱氧-9a-氮杂-9a-同型红霉素A水合物 

分 类 号：TQ465.5[化学工程—制药化工]