赛霉安阴道栓对家兔阴道粘膜刺激试验  

Vaginal mucosa irritation test of SaiMeiAn vaginal suppositories on rabbits

作　　者：刘用国[1] 王江融[1] 李鸣[1] 

机构地区：[1]福建省药品检验所,福州350001

出　　处：《海峡药学》2007年第4期27-29,共3页Strait Pharmaceutical Journal

摘　　要：目的观察赛霉安阴道栓对阴道粘膜的刺激反应。方法以家兔阴道每日持续给药4h,每日1．0g/只,连续给药10日,同时设赋型剂对照组,观察对阴道的刺激反应。结果经肉眼临床观察未见明显水肿、糜烂、出血、溃疡等病理改变,组织病理学镜检赛霉安阴道栓对家兔阴道粘膜刺激反应程度为无刺激。结论赛霉安阴道橙对阴道粘膜无刺激性。OBJECTIVE To detect the vaginal mucosa irritation of SaiMeiAn vaginal suppositories. METHODS SaiMeiAn vaginal suppositories was continuously given to vagina of rabbits 4 hours a day,the dose were 1. 0g per rabbit, givng ten days in continually. Meantime the prcipients control group were given. The irritation reactions on vagina tissues was observed. RESULTS There was no significant change in vagina tissues such as edema, blood, fester, ulcer. The tissues checked by microscope indicated that SaiMeiAn on vaginal suppositories has no irritation on vaginal mucosa. CONCLUSION The SaiMeiAn vaginal suppositories has no vaginal mucosa irritation on rabbits.

关 键 词：赛霉安阴道栓 阴道粘膜刺激 

分 类 号：R969.4[医药卫生—药理学]