新型手性不对称脲石胆酸分子裂缝的设计合成  

Design and Synthesis of Novel Chiral Lithocholic Acid-Based Molecular Clefts Containing Unsymmetrically Disubstituted Urea Unit

作　　者：周彩娥[1] 赵志刚[1] 唐晓丽[1] 

机构地区：[1]西南民族大学化学与环境保护工程学院,成都610041

出　　处：《有机化学》2007年第4期513-518,共6页Chinese Journal of Organic Chemistry

基　　金：西南民族大学自然科学基金重点(No.05NZ002)资助项目.

摘　　要：以刚性的石胆酸甲酯为骨架,手性不对称脲为侧链,通过三光气桥连,设计合成了一类新型的手性分子裂缝.7个分子裂缝均为新化合物,其结构均经1HNMR,IR,MS和元素分析确证,并且考察了其对卤素阴离子Cl-,Br-,I-的识别性能.初步的实验结果表明,这类分子裂缝不仅可与所考察的卤素阴离子形成1∶1型超分子配合物,而且对卤素阴离子具有良好的识别选择性.A novel type of chiral molecular clefts has been designed and synthesized by linking a chiral unsymmetrically disubstituted urea to rigid methyl lithocholate via triphosgene. Seven molecular clefts are new compounds. Their structures were confirmed by ~H NMR, IR, MS spectra and elemental analyses. The recognition properties of these molecular clefts for halogen anions have been investigated by UV-visible spectral titration. The preliminary results indicated that these molecular clefts not only possessed the ability to form 1 ： 1 complex with anions examined, but also showed good selectivity for halogen anions.

关 键 词：石胆酸 分子裂缝 合成 手性不对称脲 

分 类 号：O621.25[理学—有机化学]