聚乙二醇支载羧酸酯参与三级醇的液相有机合成研究  

Liquid-Phase Organic Synthesis of Tertiary Alcohols Based on Poly(Ethylene Glycol) Supported Carboxylic Esters

作　　者：桑晓燕[1] 杨兆平 盛寿日[1] 龚斌[1] 黄仁生[1] 

机构地区：[1]江西师范大学化学化工学院,江西南昌330027 [2]江西农业工程学院化学系,江西樟树331200

出　　处：《江西师范大学学报（自然科学版）》2007年第1期78-81,共4页Journal of Jiangxi Normal University(Natural Science Edition)

基　　金：国家自然科学基金(20562005);江西省自然科学基金(0620021);鄱阳湖生态环境与资源研究教育部重点实验室基金(PX2005004)资助项目

摘　　要：聚乙二醇分别与乙酰氯、苯甲酰氯和3,4-二氯苯甲酰氯在Et3N存在下方便地得到了3种聚乙二醇支撑的羧酸酯,继而与格氏试剂反应制得了一系列的三级醇.该合成方法操作简单,产率高,粗产物纯度较高.聚乙二醇支载的羧酸酯可循环使用,对环境友好.Reaction of poly（ethylene glycol） with acetyl chloride, benzoyl chloride and 3,4-dicholo benzoyl chloride in the presence of Et3N readily gave rise to the corresponding PEG bound carboxylic esters, which was treated with different Grignard reagents resulted in the generation of a tertiary alcohol library in good yields and purities with convenient manipulation and easy purification of products. These soluble polymeric reagents exhibited enough reactivity for this reaction under mild conditions. Moreover, it can be regenerated and reused as environ- mentally benign reagent.

关 键 词：聚乙二醇支载的羧酸酯 液相有机合成 三级醇 

分 类 号：O623.41[理学—有机化学]