糖尿病相关抗体与糖尿病分型及C-肽水平相关性分析  

Analysis of the Correlation of Diabetes Mellitus and levels of C-peptide with the Related DM Antibodies

作　　者：张丽[1] 张传兴[2] 王民玉[1] 姜新民[1] 

机构地区：[1]山东省千佛山医院,山东济南250014 [2]山东省血液中心,山东济南250014

出　　处：《预防医学论坛》2007年第5期393-395,共3页Preventive Medicine Tribune

摘　　要：[目的]分析糖尿病相关抗体在1型糖尿病患者和2型糖尿病患者中的分布情况,分析其与胰岛β细胞功能的关系。[方法]选取2004年3月至2005年10月在山东省千佛山医院就诊的门诊和住院糖尿病患者和健康人群,检测血中GADAI、CA、IAA及C-肽。[结果]检测1型糖尿病患者25例,2型糖尿病患者380例,健康对照组30人。GADA、ICA的阳性率1型糖尿病患者分别为76.00%、60.00%,2型糖尿病患者分别为32.11%、31.58%(P<0.01);IAA阳性率在2组病人分别为20.00%、26.31%(P>0.05)。C-肽均值(ng/ml),3种抗体均阴性组(109人)为(2.57±1.37),正常对照组(30人)为(2.07±0.68),GADA阳性组(55人)为(1.50±0.84),IAA阳性组(37人)为(1.95±1.04),ICA阳性组(46人)为(1.61±0.89),3种抗体均阳性组(25人)为(1.87±1.04)。C-肽低值组与C-肽高值组比较,IAA阳性率分别为24.21%、16.09%(P>0.05),GADA阳性率分别为43.16%、14.94%(P<0.01),ICA阳性率分别为35.80%、13.79%(P<0.01)。[结论]GADAI、CA阳性率1型糖尿病患者明显高于2型糖尿病患者,胰岛相关抗体GADA阳性者常伴有C-肽水平降低。[Objective]To analyze the distribution of the related DM antibodies in type 1, type 2 DM patients and the relationship with J3 cell function of islet. [Methods]Diabetes mellitus outpatients and inpatients in Qianfushan Hospital from March 2004 to October 2005 and healthy persons in control group were selected,GADA,IAA, ICA and C-peptide （c-p） in serum were tested. [Results]25,380, and 30 of type 1 diabetic patients（T1DM）, type 2 diabetic patients （T2DM） and healthy controls were tested respectively. The positive rate of GADA and ICA in T1DM patients was 76% and 60% ,and that in T2DM patients was 32.1% and 31.6%（ P 〈0.01）. IAA positive rate in those two groups was 20% and 26.3%（ P 〉0.05）. The levels of C-peptide （ng/ml） in the patients with three antibodies negative were （2.57 ±1.37）（109 persons） ,in control group were （2.07±0.68）（30 persons）,in GADA positive group were （1.5±0.84）（55 persons）,in IAA positive group were （1.95± 1. 043） （37 persons） ,in ICA positive group were （1.61±0.89） （46 persons） ,in the patients with three antibodies positive were （1.87± 1.04） （25 persons） IAA positive rate in C-peptide low group and high group was 24.2% and 16.1%（ P 〉0.05） ,GADA positive rate was 43.2% and 14.9% （ P 〈0. 01）and ICA positive rate was 35.8% and 13.8%（ P 〈0.01）. [Conclusion]GADA and ICA positive rate in T1DM was higher than that in T2DM. C- peptide levels were always low,when the islet antibody-GADA was positive in DM patients.

关 键 词：糖尿病 谷氨酸脱羧酶抗体(GADA) 胰岛素抗体(IAA) 胰岛细胞抗体(ICA) C-肽 

分 类 号：R587.1[医药卫生—内分泌]