2005年福州市部分人群狂犬病疫苗接种后免疫效果观察  

Observation on The Immune Effect of Some People Immunized with Rabies Vaccine in Fuzhou 2005

作　　者：陈艳[1] 徐珊[1] 杨建娜[1] 

机构地区：[1]福建省福州市疾病预防控制中心,福建福州350004

出　　处：《预防医学论坛》2007年第5期429-429,432,共2页Preventive Medicine Tribune

摘　　要：[目的]了解狂犬病纯化疫苗的免疫效果。[方法]对1407例暴露后自愿到福州市疾病预防控制中心预防医学门诊部接种人用狂犬病纯化疫苗（Vero细胞疫苗）的人群，采用酶联免疫检测方法检测狂犬病毒抗体，并对检测结果进行统计分析。[结果]共检测犬伤患者1407例，免疫后狂犬病毒抗体阳性者1327例，总阳性率为94．31％，其中男性阳性率为95．03％；女性阳性率为93．50％；男女抗体阳性率差异无统计学意义（Χ^2=1．528，P〉0．05）。不同年龄组的抗体阳性率不同，0～19岁组与20～59及60～93岁组抗体阳性率差异有统计学意义（Χ^2=15．457、13．829，P〈0．01、P〈0．05）。[结论]人用狂犬病疫苗有很好的免疫效果，但对免疫失败者应加强免疫，同时个体自身年龄对狂犬病毒抗体的形成有一定影响。[Objective]To understand the immune effect of rabies vaccine. [Methods]The antibodies of 1407 individuals were detected by ELISA and the results were analyzed with SPSS program. Those people were immunized with rabies vaccine （Vero cell） in Fuzhou CDC after exposure. [Results]A total of 1 407 injured persons were investigated,the antibody was tested after immunization, 1 327 of them were positive, the total positive rate was 94.31%, the positive rate in male was 95.03% ,in female was 93.50%, there was no difference of the positive rate between male and female. （ Χ^2 = 1. 528, P 〉 0.05）. The results showed that the positive rate was different between different age groups. There was significant difference of the positive rate in 0-19 ,20-59 and 60-93 age groups （ Χ^2= 15. 457,13. 829; P 〈0.01, P〈 0.05）. [Conclusion]The rabies vaccine had good immune effect,but the failures should be immunized, for booster injection and the antibody was affected by the ages of individuals in some extent.

关 键 词：狂犬病 抗体 狂犬病疫苗 免疫效果 

分 类 号：R512.91[医药卫生—内科学]