人尾加压素Ⅱ与高血压病及急性冠脉综合征的关系  

Association of Plasma UrotensinⅡ with Hypertension and Acute Coronary Syndrome

作　　者：高宇[1] 李红伟[1] 李明子[2] 黄丽红[1] 

机构地区：[1]吉林大学中日联谊医院,吉林长春130033 [2]吉林市中心医院,吉林吉林132000

出　　处：《中国实验诊断学》2007年第4期454-456,共3页Chinese Journal of Laboratory Diagnosis

摘　　要：目的研究高血压病及急性冠脉综合征患者的人尾加压素(hUⅡ)水平变化。方法采用放射免疫分析法检测血浆hUⅡ含量。结果正常对照组血浆UⅡ含量为5.52±0.93 pg/ml;高血压病组、不稳定型心绞痛组、急性心肌梗死组及高血压合并不稳定型心绞痛组血浆UⅡ水平分别为3.5±1.06 pg/ml,3.86±1.68 pg/ml,2.43±0.98 pg/ml,2.67±0.85 pg/ml,均明显低于正常对照组(均为P<0.01)。不稳定型心绞痛及急性心肌梗死血浆UⅡ水平有明显差异(P<0.05)。结论hUⅡ可能在高血压病及急性冠脉综合征的病理生理过程中发挥着十分重要的作用,并与不稳定斑块所致心肌缺血程度可能相关。Objective To investigate changes of plasma urotensin Ⅱ （UⅡ） levels in patients with essential hypertension（EH）, unstable angina （UA）, acute myocardial infarction（ AMI ） and U A combined EH（UE）, to study the probably pathophysiological roles of UⅡ in these diseases .Methods Peripheral venous blood was collected in EDTA from normal healthy controls and patients ,the blood was then centrifuged and plasma was collected , U Ⅱ levels in plasmas were measured by radioimmuncoassay, and both of plasma TC and TG; were determined by enzymatic methods.Results the mean plasma U Ⅱ level in healthy controls was 5.52 ± 0.93pg/ ml. In patients with EH,UA,AMI（in 6 hours after myocardial infarction）and UE ,the mean plasma UⅡ level were 3.50± 1.06pg / ml,3.86 ± 1.68 pg/ml, 2.43 ± 0.98pg/ml, 2.67 ± 0.85pg/ml, respectively, which were significantly lower than that in control group （ P 〈 0.01 ） .Furthermore,there were significant differences between patients with AMI and UA（ P 〈 0.01）. There were no significant differences between EH 2 grade and EH 3 grade in EH group（ P 〉 0.05）. Conclusion The plasma U Ⅱ in patients with EH,UA,AMI were decreased significantly and this suggests that UⅡ might participate in the pathophysiological processes of the diseases. There were significant differences between patients with UA and AMI, and this suggests that U Ⅱ might correlate with the degrees of cardiac ischemia resulted from unstable atherosclerotic plaques.

关 键 词：尾加压素Ⅱ(UⅡ) 放射免疫分析法 高血压病 急性冠脉综合征 

分 类 号：R544.1[医药卫生—心血管疾病] R541.4[医药卫生—内科学]