慢性HBV感染患者血清中HBsAg与抗-HBs两种标志物同时阳性罕见模式的分析  

Analysis of the rare HBV marker model with HBsAg and HBsAb simultaneously positive in the serum of patients with chronic Hepatitis B virus infection

作　　者：张立丽[1] 辛永梅[1] 赵秀英[1] 闫惠平[1] 

机构地区：[1]北京佑安医院临检中心,北京100069

出　　处：《中国实验诊断学》2007年第4期476-478,共3页Chinese Journal of Laboratory Diagnosis

摘　　要：目的通过分析慢性HBV感染患者乙型肝炎病毒(HBV)血清学标志物HBsAg与抗-HBs同时阳性这种罕见模式的病例,来探讨其存在的原因及临床价值。方法采用电化学发光法(ECLIA)检测患者血清中的HBsAg,抗-HBs,HBeAg,抗-HBe,抗-HBc,5种标志物,采用荧光定量聚合酶链反应(FQ-PCR)检测HBV DNA。结果HBsAg与抗-HBs同时阳性的罕见模式组仍有病毒复制。应用HBIG治疗失败时可以出现HBsAg与抗-HBs同时阳性。结论HB-sAg和抗-HBs同时阳性并非疾病真正好转的指标。Objective To discuss the cause and the clinical value about the rare model that HBsAg and anti-HBs Simultaneously positive in the serum of patients with chronic Hepatitis B virus infection. Methods Detected the HBsAg, anti-HBs,HBeAg, anti- HBe, anti-HBc in the serum of patients with chronic Hepatitis B virus infection by the Electrochemiluminescence immunoassay（ECLIA） and HBV DNA by Fluorescence quantitative polymerase chain reaction （FQ-PCR）.Results HBV DNA replication was occurred in the rare model group. HBsAg and anti-HBs simultaneously positive when the treatment was failed with HBIG. Conclusion It doen＇ t represent the disease recovery that HBsAg and anti-HBs simultaneously positive.

关 键 词：乙型肝炎病毒 血清学标志物 荧光定量聚合酶链反应 

分 类 号：R512.62[医药卫生—内科学]