小肠脂肪酸结合蛋白基因的研究进展  

Recent progress on the intestinal fatty acid binding protein gene

作　　者：李竹[1] 陈莉明[1] 

机构地区：[1]天津医科大学代谢病医院糖尿病肾病科,300070

出　　处：《国际内分泌代谢杂志》2007年第B04期4-5,共2页International Journal of Endocrinology and Metabolism

摘　　要：小肠脂肪酸结合蛋白（FABP2）是由小肠单层柱状上皮细胞分泌的一种蛋白质，具有将长链脂肪酸从细胞膜转运至内质网的功能。编码该蛋白的基因存在多个位点多态性，外显子2中第54位上腺嘌呤和鸟嘌呤的置换会引起结合脂肪酸能力的变化，进而导致脂肪酸进入体内的量发生变化。由于在调节脂肪酸代谢方面的作用，该位点多态性与胰岛素抵抗、2型糖尿病及其并发症的发生密切相关。The intestinal fatty acid binding protein（FABP2） is secreted by the absorptive simple columnar epithelial cells of the small intestine. In these cells, FABP2 transports long-chain fatty acids from the plasma membrane, through the aqueous cytosol, to the endoplasmic reticulum. Numerous studies have assessed FABP2 gene variations. An A for G substitution in codon 54 of exon 2 may change its ability of binding fatty acids, and then the quantity of fatty acids in vivo will change. Ala54Thr polymorphisrn is concerned with insulin resistance, type 2 diabetes and its complications.

关 键 词：小肠脂肪酸结合蛋白 基因多态性 胰岛素抵抗 糖尿病 

分 类 号：R587.1[医药卫生—内分泌]