具灭螺活性的吡喃型异黄酮Alpinumisoflavone的合成研究  

Synthesis of Alpinumisoflavone with molluscicidal activity

作　　者：李洁[1] 姜志宽[1] 

机构地区：[1]南京军区军事医学研究所,江苏南京210002

出　　处：《中华卫生杀虫药械》2007年第2期124-125,共2页Chinese Journal of Hygienic Insecticides and Equipments

基　　金：国家自然科学基金项目(NO.30450003);江苏省自然科学基金项目(BK2004010)

摘　　要：目的化学法合成具灭螺活性的吡喃异黄酮类化合物—Alpinumisoflavone。方法以多元酚和取代苯乙酸衍生物为主要原料经二步合成得到产物。结果合成了Alpinumisoflavone,产物结构经理化常数和1H-NMR谱确证。这为进一步生物筛选新型灭螺剂提供样品。结论以3-羟基-3-甲基-1,1-二甲氧基丁烷作为二甲基色烯化试剂合成Alpinumisoflavone色烯环工艺简便。Objective To synthesis pyranoisoflavonids compound-alpinumisoflavone with strong molluscicidal activity. Methods Polyhydric phenols and p-substituted phenylacetic acid derivatives were used as the major reactants to obtain the target compounds by multi-step synthesis. Results The target compound structure were comfirmed by physicial constant and ^1H-NMR spectrum. Alpinumisoflavone had been synthesized, so that to supply sample for further biological screening. Conclusion It was a stable and readily accessible routine for synthesis of dimethylchromens of Alpinumisoflavone and its derivatives while 3-Hydroxy-3 - methyl-1, 1-dimethoxybutane was used as dimethylchromenylation reagent. Pyranoisoflavone molluscicidal activity sceening results were to be reported in other paper.

关 键 词：吡喃型异黄酮 Alpinumisoflavone 灭螺剂 合成 二甲基色烯化试剂 

分 类 号：S482.59[农业科学—农药学]