乳洁安胶囊的镇痛作用  

Experimental Study on the Analgesic Effect and Toxicity of Rujiean Capsule

作　　者：王燕燕[1] 杨洪发[1] 陈超[2] 宋兴福[1] 黄骥[1] 

机构地区：[1]三峡大学第一临床医学院宜昌市中心人民医院,湖北宜昌443003 [2]三峡大学医学院药理教研室,湖北宜昌443002

出　　处：《中国现代应用药学》2007年第2期165-168,共4页Chinese Journal of Modern Applied Pharmacy

基　　金：湖北省科技攻关计划项目(编号:2004AA301C49)

摘　　要：目的观察乳洁安胶囊的镇痛作用。方法采用小鼠扭体法、热板法、蛋清致大鼠肿胀足组织中前列腺素E2(PGE2)含量的测定、观察乳洁安胶囊的镇痛作用。结果乳洁安胶囊中、高剂量组能明显减少醋酸致小鼠扭体反应次数,提高小鼠的痛阈值;随着剂量的增加其镇痛作用有增强的趋势,同时具有明显抑制大鼠足肿组织中PGE2产生的作用。结论乳洁安胶囊具有较好的镇痛作用。OBJECTIVE To study the analgesic effects of Rujiean capsule. METHODS By using acetic acid-induced writhing test and hot-plate test in mice, and the detection of prostaglandin E2 （ PGE2 ） levels in egg albumin-induced rat paw edema tissue, the analgesic effects of Rujiean capsule were observed. RESULTS Middle and high doses of Rujiean capsule significantly reduced the number of acetic acid-induced writhing and increased the response latency in mice. With the increase of the dosage of Rujiean capsule, the analgesic effects had an increased tendency, and the PGE2 production in egg albumin-induced rat paw edema tissue was obviously inhibited simultaneously. CONCLUSION Rujiean capsule had a satisfactory analgesic effects.

关 键 词：乳洁安胶囊 镇痛作用 

分 类 号：R285.6[医药卫生—中药学]