IL1ra、TNFα、US-CRP与多囊卵巢综合征发病的相关性研究  

Study on the correlation between interleukin 1 receptor antagonist,tumour necrosis factor alpha,high sensitivity C-reactive protein and pathogenesis of polycystic ovary syndrome

作　　者：杨艳[1] 胡卫红[2] 乔杰[1] 李美芝[1] 

机构地区：[1]北京大学第三医院妇产科,100083 [2]北京武警总医院,100039

出　　处：《中国优生与遗传杂志》2007年第5期35-37,共3页Chinese Journal of Birth Health & Heredity

基　　金：国家自然科学基金资助(项目编号:30570872)

摘　　要：目的探讨血清炎症因子白细胞介素1受体拮抗剂(IL1ra)、肿瘤坏死因子(TNFα)、血超敏C反应蛋白(US-CRP)与多囊卵巢综合征(PCOS)发病的关系。方法采用酶放大化学发光法分别检测30例PCOS无糖尿病患者及30例正常对照组血清卵泡刺激素(FSH)、黄体生成素(LH)和睾酮(T)水平;葡萄糖氧化酶法测定血清空腹血糖(GLU)水平;酶联免疫吸附试验(ELISA)方法血清IL1ra、TNFα水平;用乳胶增强免疫比浊法检测血清US-CRP水平。并用统计学方法分析两实验组中各血清成分水平差异,以及各检测指标之间的相关关系。结果(1)PCOS组LH、T、LH/FSH、IL1ra、TNFα、US-CRP水平明显高于正常组,PCOS组FSH水平低于对照组,差异有显著性(P<0.05)。(2)PCOS组血清IL1ra、TNFα、US-CRP、T水平与体重指数(BMI)呈正相关(P<0.05)。(3)PCOS组血清IL1ra、TNFα、US-CRP水平与LH/FSH和睾酮水平呈正相关(P<0.05)。(4)两组血清IL1ra、US-CRP、TNFα水平存在正相关。结论炎症因子IL1ra、TNFα、US-CRP在多囊卵巢综合征患者血清中明显升高,提示慢性亚临床炎症可能与多囊卵巢综合征发病相关。Objective： To study the correlation between serum inflammation factor interleukin 1 receptor antagonist, tumour necrosis factor alpha, high sensitivity C - reactive protein and pathogenesis of polycystic ovary syndrome. Methods. Thirty cases of PCOS （ PCOS group） and thirty cases of normal reproductive age female （ control group） were studied in this experiment. Serum levels of follicle- stimulating hormone, luteinizing hormone, testosterone were examined by chemiluminescent immunoassay; Serum levels of interleukin 1 receptor antagonist, necrosis factor alpha were examined by ELISA ; Serum C - reactive protein levels were examined by sdaptation of Latex - enhanced assay. To analyse the difference of serous components between PCOS group and control group, and correlation between the levels of these serous components. Results： （1） Serum levels of luteinizing hormone, testosterone, LH/FSH, ILl ra, TNFα and US - CRP in PCOS group were higher than those in control group, serum levels of follicle - stimulating hormone were lower than those in control group. （2） Serum levels of IL1ra, TNFα, US -CRP, T in PCOS group were positively related to body mass index. （3） Serum levels of ILlra, TNFα and US -CRP were positively related to LI-I/FSH and testosterone in PCOS group. （4） Serum levels of IL1ra,TNFα, US-CRP have positively relation in both groups. Conclusion： Serum levels of IL1ra, TNFα, US -CRP in PCOS group were higher than those in control group, low - grade chronic inflammation may have correlation with pathogenesis of PCOS.

关 键 词：多囊卵巢综合征 白细胞介素1受体拮抗剂 肿瘤坏死因子 超敏C反应蛋白 

分 类 号：R711.75[医药卫生—妇产科学]