Synthesis and NHE1 inhibitory activity of ligustrazine derivatives  

作　　者：Mei Ren Yun Gen Xu Na Wen Da Yong Zhang Wei Yi Hua 

机构地区：[1]Center of Drug Discovery, China Pharmaceutical University, Nanjing 210009, China [2]Department of Pharmacology, China Pharmaceutical University, Nanjing 210009, China

出　　处：《Chinese Chemical Letters》2007年第5期539-541,共3页中国化学快报（英文版）

摘　　要：A series of novel derivatives of ligustrazine linked with substituted benzoyl guanidine were synthesized. These compounds have not been reported in literature, and their chemical structures were confirmed by IR, ^1H NMR and MS. The results of NHE1 inhibitory activity test showed that compounds I2, I3, I4, I6, and I7 possess more potent NHE1 inhibitory activity than cariporide.A series of novel derivatives of ligustrazine linked with substituted benzoyl guanidine were synthesized. These compounds have not been reported in literature, and their chemical structures were confirmed by IR, ^1H NMR and MS. The results of NHE1 inhibitory activity test showed that compounds I2, I3, I4, I6, and I7 possess more potent NHE1 inhibitory activity than cariporide.

关 键 词：Na^＋/H^＋ exchanger inhibitors Ligustrazine derivatives Benzoyl guanidine derivatives SYNTHESIS 

分 类 号：R284.3[医药卫生—中药学]