脂联素基因多态性与2型糖尿病大血管病变的关系  

Relationship between polymorphism of adiponectin gene and type 2 diabetes with vascular dieases

作　　者：张红霞[1] 李茵茵[1] 邹彩艳[1] 李秋[1] 陈海燕[1] 王哲[1] 

机构地区：[1]山东省立医院,山东济南250021

出　　处：《山东医药》2007年第10期1-2,共2页Shandong Medical Journal

基　　金：山东省保健医学科研课题项目

摘　　要：目的研究脂联素基因多态性与2型糖尿病(T2DM)大血管病变的关系。方法采用聚合酶链式反应-限制性片段长度多态性技术对198例T2DM患者和98例正常对照组进行脂联素基因多态性分析。结果对照组脂联素+276TT基因型频率较患者组明显增多(P<0.01);T2DM组有无大血管病变患者无明显差异。结论脂联素+276G>T多态性与T2DM相关,携带TT基因型可能减少患T2DM的几率;其多态性与T2DM大血管病变无明显相关性。[Objective] To explore the relationship between ＋276G〉T polymorphism of adiponectin gene and type 2 diabetic with vascular diseases. [Methods] For the case-control study,polymerase chain reaction-restriction fragment length polymorphism assay （PCR-RFLP） method was used to determine the distribution of geuotype frequencies of ＋276G〉T polymorphism of the adiponectin gene in 198 cases of type 2 diabetes and 98 normal control subjects. [Results] The frequencies of ＋276TT homozygotes were significantly increased in control subjects compared with type 2 diabetes （P〈0. 01）. There was no significant difference in the distribution of genotype between type 2 diabetes with or without vascular dieases. [Conclusion] The result suggests that the ＋276G〉T polymorphism of adiponectin gene is associated with type 2 diabetes in Shandong Han population, those with the ＋276TT homozygotes have lower risk of type 2 diabetes. The ＋276G〉T polymorphism has no obvious association in type 2 diabetes with vascular diseases.

关 键 词：脂联素 基因多态性 糖尿病 2型 大血管病变 

分 类 号：R541[医药卫生—心血管疾病]