呕必宁对顺铂所致脑组织5-HT含量变化的影响  

Effect of Oubining on Cisplatin Causing 5-HT Level Change in the Brain

作　　者：王德山[1] 单德红[1] 于化新[1] 柴继严[1] 

机构地区：[1]辽宁中医药大学,辽宁沈阳110032

出　　处：《中华中医药学刊》2007年第5期869-871,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：辽宁省教育厅基金资助课题(20040228)

摘　　要：目的:探讨中药复方呕必宁防治化疗药诱发呕吐的中枢机制。方法:应用行为学与分子生物学的方法,比较对照组、NS组、中药组实验动物静脉注射DDP前后,动物呕吐反应,血、脑脊液中DDP浓度,脑脊液、脑组织中的5-HT、5-HIAA含量变化。结果:注射DDP后与NS组比较,中药组猫的呕吐率下降;与此同时脑脊液中DDP浓度明显低于NS组、脑脊液及脑组织中5-HT和5-HIAA浓度较NS组显著降低。结论:呕必宁对DDP所致呕吐反应具有防治作用,其机制可能与降低猫脑脊液中DDP的浓度,降低脑脊液、脑组织中5-HT、5-HIAA含量有关。Objective： To study the central mechanism of oubining prevention action to vomiting induced by chemotherapy. Methods： Vomiting frequency, eisplatin （DDP） concentrations in plasma and cerebrospinal fluid, and 5 -HT, 5 - HIAA concentrations in eerebrospinal fluid and medullary tissue were detected before and after intravenous administration of DDP in cats of tile control, saline （NS） group and oubining group. Results： After intravenous administration of DDP, vomiting frequency, DDP concentrations in the eerebrospinal fluid, 5 - HT and 5 - HIAA concentrations in the medullary tissues of cats in oubining group were lower than those in the NS group. Conclusion： Oubining can prevent vomiting induced by DDP and its mechanism is relative to the decreases of DDP, 5 - HT and 5 - HIAA concentrations in cerebrospinal fluid and medullary tissues.

关 键 词：呕必宁 化疗呕吐 DDP 5-HT 5-HIAA 

分 类 号：R286[医药卫生—中药学]