Enantioselective Alkynylation of Ketones Promoted by β-Sulfonamide Alcohol-Titanium Complexes  

作　　者：倪明 周益峰 陈超 许江珂 王锐 

机构地区：[1]State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, Gansu 730000, China [2]Department of Biology, Hubei Normal University, Huangshi, Hubei 435002, China [3]State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, Gansu 730000, China

出　　处：《Chinese Journal of Chemistry》2007年第5期694-697,共4页中国化学（英文版）

基　　金：Project suported by the National Natural Science Foundation of China （Nos. 20372028, 20472026, 20525206, 20021001） and the Specialized Research Fund for the Doctoral Program in Higher Education Institutions of the Ministry of Education of China.

摘　　要：A readily available β-sulfonamide alcohol-titanium complex was found to be effective on promoting the asymmetric addition reaction of an alkynylzinc reagent to unactivated simple ketones under very mild conditions. And the corresponding chiral tertiary propargylic alcohols were obtained with enantiomeric excesses of up to 86%, which provided a simple, practical and inexpensive method to generate chiral tertiary propargylic alcohols.A readily available β-sulfonamide alcohol-titanium complex was found to be effective on promoting the asymmetric addition reaction of an alkynylzinc reagent to unactivated simple ketones under very mild conditions. And the corresponding chiral tertiary propargylic alcohols were obtained with enantiomeric excesses of up to 86%, which provided a simple, practical and inexpensive method to generate chiral tertiary propargylic alcohols.

关 键 词：KETONE asymmetric ALKYNYLATION β-sulfonamide alcohol catalysis 

分 类 号：O621.255.8[理学—有机化学]